ArticleJournal of neurophysiology2012
Suppression of spikes during posttetanic hyperpolarization in auditory neurons: the role of temperature, I(h) currents, and the Na(+)-K(+)-ATPase pump.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- An interaction between PRRT2 and NaCell death & disease · 2021Article
- How to Build a Fast and Highly Sensitive Sound Detector That Remains Robust to Temperature Shifts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons.eLife · 2019Article
- Regulation of Neuronal NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan.Frontiers in cellular neuroscience · 2019Article
- Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.Current biology : CB · 2018Article
- The Calyx of Held: A Hypothesis on the Need for Reliable Timing in an Intensity-Difference Encoder.Neuron · 2018Review
- Differential contributions of CaHippocampus · 2018Article
- Sodium pump regulation of locomotor control circuits.Journal of neurophysiology · 2017Review
- Resistance to action potential depression of a rat axon terminal in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- In vivo matching of postsynaptic excitability with spontaneous synaptic inputs during formation of the rat calyx of Held synapse.The Journal of physiology · 2017Article
- Neurotransmitter Release Can Be Stabilized by a Mechanism That Prevents Voltage Changes Near the End of Action Potentials from Affecting Calcium Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Mechanisms underlying the activity-dependent regulation of locomotor network performance by the Na+ pump.Scientific reports · 2015Article
- Reduction in neural performance following recovery from anoxic stress is mimicked by AMPK pathway activation.PloS one · 2014Article
- The sodium-potassium pump is an information processing element in brain computation.Frontiers in physiology · 2014Article
- Central dysmyelination reduces the temporal fidelity of synaptic transmission and the reliability of postsynaptic firing during high-frequency stimulation.Journal of neurophysiology · 2013Article
- Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity.The Journal of physiology · 2013Article
- A sodium-pump-mediated afterhyperpolarization in pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
In vivo recordings from postsynaptic neurons in the medial nucleus of the trapezoid body (MNTB), an auditory brain stem nucleus, show that acoustic stimulation produces a burst of spikes followed by a period of hyperpolarization and suppressed spiking activity. The underlying mechanism for this hyperpolarization and reduced spiking is unknown. Furthermore, the mechanisms that control excitability and resting membrane potential are not fully determined for these MNTB neurons. In this study we investigated the excitability of principal neurons from the MNTB after high-frequency afferent fiber stimulation, using whole cell recordings from postnatal day 15-17 rat brain stem slices. We found that Na(+)-K(+)-ATPase activity mediates a progressive hyperpolarization during a prolonged tetanic train and a posttetanic hyperpolarization (PTH) at the end of the train, when postsynaptic action potentials failed to fire. Raising the temperature to more physiological levels (from 22 to 35°C) depolarized the resting membrane potential of both presynaptic and postsynaptic cells and decreased the latency of action potential firing during PTH. Higher temperatures also reduced the presynaptic calyx action potential failure rates by 50% during presynaptic PTH, thus increasing the safety-factor for presynaptic spiking. The effect of temperature on hyperpolarization-activated cation current (I(h)) is reflected in the resting potential at both pre- and postsynaptic neurons. We thus propose that temperature-sensitive Na(+)-K(+)-ATPase activity and I(h) contribute to set the resting membrane potential and produce a brief period of suppressed spiking (or action potential failures) after a prolonged high-frequency afferent tetanus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.