ReviewGenetics2012
Notch and the awesome power of genetics.
Review in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- Regulation of hlh-2 transcription during specification of the anchor cell of the C. elegans hermaphrodite gonad.G3 (Bethesda, Md.) · 2026Article
- From nematode to Nobel: How community-shared resources fueled the rise ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Essential and dual effects of Notch activity on a natural transdifferentiation event.Nature communications · 2025Article
- DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells.Nature communications · 2024Article
- Article
- An expandable FLP-ON::TIR1 system for precise spatiotemporal protein degradation in Caenorhabditis elegans.Genetics · 2023Article
- Endothelial Cell Fate Determination: A Top Notch Job in Vascular Decision-Making.Cold Spring Harbor perspectives in medicine · 2022Review
- Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins.Current biology : CB · 2022Article
- SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo.Developmental cell · 2022Article
- Influences of HLH-2 stability on anchor cell fate specification during Caenorhabditis elegans gonadogenesis.G3 (Bethesda, Md.) · 2022Article
- Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Positive autoregulation ofDevelopment (Cambridge, England) · 2020Article
- Biology of theGenetics · 2019Review
- A Screen of the Conserved Kinome for Negative Regulators of LIN-12 Negative Regulatory Region ("NRR")-Missense Activity inG3 (Bethesda, Md.) · 2019Article
- Developmental Plasticity and Cellular Reprogramming inGenetics · 2019Review
- HLH-2/E2A Expression Links Stochastic and Deterministic Elements of a Cell Fate Decision during C. elegans Gonadogenesis.Current biology : CB · 2019Article
- Multi-Faceted Notch in Allergic Airway Inflammation.International journal of molecular sciences · 2019Review
- OrthoList 2: A New Comparative Genomic Analysis of Human andGenetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Notch is a receptor that mediates cell-cell interactions in animal development, and aberrations in Notch signal transduction can cause cancer and other human diseases. Here, I describe the major advances in the Notch field from the identification of the first mutant in Drosophila almost a century ago through the elucidation of the unusual mechanism of signal transduction a little over a decade ago. As an essay for the GENETICS Perspectives series, it is my personal and critical commentary as well as an historical account of discovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.