Evidence map›Paper›PMID 22785080›Full record

ArticleChemical communications (Cambridge, England)2012

Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography.

Yunan Yang, Youhong Niu, Hao Hong, Haifan Wu, Yin Zhang, Jonathan W Engle, Todd E Barnhart, Jianfeng Cai, Weibo Cai

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Antimicrobial AApeptides.Current topics in medicinal chemistry · 2017
    Review
  7. The development of antimicrobial γ-AApeptides.Future medicinal chemistry · 2016
    Review
  8. γ-AApeptides as a New Class of Peptidomimetics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016
    Article
  9. γ-AApeptides: Design, Structure, and Applications.Accounts of chemical research · 2016
    Article
  10. Article
  11. Design, synthesis and characterization of fMLF-mimicking AApeptides.Chembiochem : a European journal of chemical biology · 2014
    Article
  12. Short antimicrobial lipo-α/γ-AA hybrid peptides.Chembiochem : a European journal of chemical biology · 2014
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yunan YangDepartment of Radiology, University of Wisconsin - Madison, WI 53705, USA.
Youhong Niu
Hao Hong
Haifan Wu
Yin Zhang
Jonathan W Engle
Todd E Barnhart
Jianfeng Cai
Weibo Cai

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

A γ-AApeptide-based tracer for positron emission tomography imaging of integrin α(v)β(3) is reported. Despite its shorter sequence and linear nature, this tracer had comparable integrin α(v)β(3) binding affinity to the cyclic arginine-glycine-aspartic acid peptide but significantly higher resistance to enzymatic degradation and better stability.

Indexed as

AnimalsCell Line, TumorCopper RadioisotopesHumansIntegrin alphaVbeta3Isotope LabelingMicePeptides, CyclicPositron-Emission TomographyPronaseProtein BindingRadiopharmaceuticalsTissue DistributionTransplantation, HeterologousCopper Radioisotopescyclic arginine-glycine-aspartic acid peptideIntegrin alphaVbeta3Peptides, CyclicPronaseRadiopharmaceuticals

Identifiers

PMID22785080
PMCPMC3397393

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.