ReviewJournal of human hypertension2013
Salt, aldosterone and hypertension.
Review in Journal of human hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of a low-sodium diet in patients with idiopathic hyperaldosteronism: a randomized controlled trial.Frontiers in endocrinology · 2023Trial
- Primary aldosteronism.Nature reviews. Disease primers · 2026Review
- Left ventricle remodeling by CMR in treated patients with primary aldosteronism and primary systemic arterial hypertension.PloS one · 2024Article
- VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.Cardiovascular research · 2023Article
- Mechanisms of Post-critical Illness Cardiovascular Disease.Frontiers in cardiovascular medicine · 2022Review
- Salt Sensation and Regulation.Metabolites · 2021Review
- Article
- Epithelial Sodium Channel and Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Review
- [Hyperaldosteronism].Der Internist · 2021Review
- Patients With Primary Aldosteronism Respond to Unilateral Adrenalectomy With Long-Term Reduction in Salt Intake.The Journal of clinical endocrinology and metabolism · 2020Observational
- Apneic Sleep, Insufficient Sleep, and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Aldosterone induces rapid sodium intake by a nongenomic mechanism in the nucleus tractus solitarius.Scientific reports · 2016Article
- Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis.Journal of the American Heart Association · 2016Article
- Chemoreflex physiology and implications for sleep apnoea: insights from studies in humans.Experimental physiology · 2015Review
- Chemoreflexes, sleep apnea, and sympathetic dysregulation.Current hypertension reports · 2014Review
- Mineralocorticoid-induced sodium appetite and renal salt retention: evidence for common signaling and effector mechanisms.Nephron. Physiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical studies have shown that aldosterone and salt are independently related to hypertension, cardiovascular morbidity and mortality. More recently, studies in humans have demonstrated that, similarly to animals, endogenous aldosterone and dietary salt intake have not only separate, but also combined effects to accelerate target-organ deterioration. The aldosterone-salt interaction has important clinical implications, because combined effects of both can be minimized, if not avoided, by reducing salt intake. This interaction could also be interrupted by blocking the effects of aldosterone, with use of mineralocorticoid receptor antagonists, or by reducing aldosterone effects by adrenalectomy, in patients with aldosterone producing adenoma. Furthermore, aldosterone reduction or blockade may reduce salt appetite.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.