ArticleNucleic acids research2012
The core regulation module of stress-responsive regulatory networks in yeast.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Functional network motifs defined through integration of protein-protein and genetic interactions.PeerJ · 2022Article
- IMCC: A Novel Quantitative Approach Revealing Variation of Global Modular Map and Local Inter-Module Coordination Among Differential Drug's Targeted Cerebral Ischemic Networks.Frontiers in pharmacology · 2021Article
- Depicting the Core Transcriptome Modulating Multiple Abiotic Stresses Responses in Sesame (International journal of molecular sciences · 2019Article
- Mining the Synergistic Core Allosteric Modules Variation and Sequencing Pharmacological Module Drivers in a Preclinical Model of Ischemia.CPT: pharmacometrics & systems pharmacology · 2018Article
- Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast.BMC systems biology · 2017Article
- Quantitative assessment of gene expression network module-validation methods.Scientific reports · 2015Article
- Comparative transcriptome analysis of microsclerotia development in Nomuraea rileyi.BMC genomics · 2013Article
- Computational solutions for omics data.Nature reviews. Genetics · 2013Review
- Plant core environmental stress response genes are systemically coordinated during abiotic stresses.International journal of molecular sciences · 2013Article
- Conserved versatile master regulators in signalling pathways in response to stress in plants.AoB PLANTS · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How does a cell respond to numerous external stresses with a limited number of internal molecular components? It has been observed that there are some common responses of yeast to various stresses, but most observations were based on gene-expression profiles and only some part of the common responses were intensively investigated. So far there has been no system-level analysis to identify commonly responsive or regulated genes against various stresses. In this study, we identified a core regulation module (CRM), a commonly involved regulation structure in the regulatory networks of yeast, which cells reuse in response to an array of environmental stresses. We found that regulators in the CRM constitute a hierarchical backbone of the yeast regulatory network and that the CRM is evolutionarily well conserved, stable against genetic variations and crucial for cell growth. All these findings were consistently held up to considerable noise levels that we introduced to address experimental noise and the resulting false positives of regulatory interactions. We conclude that the CRM of yeast might be an evolutionarily conserved information processing unit that endows a cell with enhanced robustness and efficiency in dealing with numerous environmental stresses with a limited number of internal elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.