SynthesisSchizophrenia research2012
The COMT Met158 allele and violence in schizophrenia: a meta-analysis.
Synthesis in Schizophrenia research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Suicidal risk in patients with aggression in schizophrenia: a systematic review.Frontiers in psychiatry · 2025Pooled it
- The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Neuromolecular medicine · 2016Pooled it
- The influence of the COMT Val158Met polymorphism on prefrontal TDCS effects on aggression.Scientific reports · 2024Trial
- Evaluating the PANSS using item response theory in forensic psychiatric samples from five European nations.Schizophrenia (Heidelberg, Germany) · 2025Article
- Association of Lower COMT Activity Alleles with Aggressive Traits in Male Youth with Conduct Disorder Living in a Correctional Facility.Biomolecules · 2025Article
- Effects of childhood trauma on aggressive behaviors and hippocampal function: the modulation of COMT haplotypes.Psychoradiology · 2023Article
- Childhood Trauma, the Combination of MAO-A and COMT Genetic Polymorphisms and the Joy of Being Aggressive in Forensic Psychiatric Patients.Brain sciences · 2021Article
- Catechol-Frontiers in psychology · 2020Article
- Clonal Characteristics of T-Cell Receptor Repertoires in Violent and Non-violent Patients With Schizophrenia.Frontiers in psychiatry · 2018Article
- Vulnerable combinations of functional dopaminergic polymorphisms to late-onset treatment resistant schizophrenia.PloS one · 2018Article
- Metyrosine treatment in a woman with chromosome 22q11.2 deletion syndrome and psychosis: a case study.International journal of developmental disabilities · 2017Article
- New Clinically Relevant Findings about Violence by People with Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Review
- Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI andNeuropsychiatric disease and treatment · 2017Article
- Role of CB2 receptors in social and aggressive behavior in male mice.Psychopharmacology · 2015Article
- Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Frontiers in psychiatry · 2015Review
- The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies.Current neuropharmacology · 2015Review
- Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- The influence of COMT Val¹⁵⁸Met genotype on the character dimension cooperativeness in healthy females.Brain and behavior · 2014Article
- Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission.Frontiers in behavioral neuroscience · 2014Review
- Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort.Journal of psychiatric research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe Met158 allele of catechol-O-methyl transferase (COMT) gene is associated with increased levels of catecholamines in the prefrontal cortex and may increase the likelihood of aggressiveness. We conducted a meta-analysis to test the hypothesis that the Met158 allele of the COMT gene is associated with aggressive and violent behavior in schizophrenia.
methodsMEDLINE search (12/31/11) yielded 14 studies examining the association of the COMT gene polymorphism (rs4680) and aggression in schizophrenia (total n=2219). Three separate analyses were conducted using a random effects model for Met allele carriers vs. Val/Val homozygotes, Met/Met homozygotes vs. Val allele carriers, and Met allele vs. Val allele, respectively. Primary outcome was frequency of patients with aggressive behavior and odds ratio (OR) was the effect size measure.
resultsThe frequency of violent patients in the sample ranged from 20% to 75%. The pooled effect sizes for the Met homozygotes vs. Val allele carriers, Met allele carriers vs. Val homozygotes and the Met allele vs. Val allele comparisons were 1.74, 1.65 and 1.35, ps<.05, respectively, suggesting that the Met 158 allele of the COMT gene is associated with higher risk for violence in schizophrenia. Results remained significant after examining heterogeneity among samples and potential publication biases.
conclusionsThe Met158 allele of the COMT gene confers a significantly increased risk for aggressive and violent behavior in schizophrenia. These data may provide basis for developing informative strategies for reducing violence in patients with schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.