ReviewThe New England journal of medicine2012
Management of opioid analgesic overdose.
Review in The New England journal of medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03845699 (Development of an Algorithm That Predicts Hypoventilation Due to an Opioid Overdose), which is not on this map. Cited by 200 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of an Algorithm That Predicts Hypoventilation Due to an Opioid Overdose
Who cites it
200 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Oxygen Saturation Thresholds for Opioid-induced Respiratory Depression: A Systematic Review.The western journal of emergency medicine · 2026Pooled it
- Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A systematic review.Drug and alcohol dependence · 2021Pooled it
- Systematic review of the emerging literature on the effectiveness of naloxone access laws in the United States.Addiction (Abingdon, England) · 2021Pooled it
- The Emergency Department as an Opportunity for Naloxone Distribution.The western journal of emergency medicine · 2018Pooled it
- ACMT and AACT Position Statement: Preventing Occupational Fentanyl and Fentanyl Analog Exposure to Emergency Responders.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2017Guideline
- Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic-clonic seizures.Epilepsia open · 2025Trial
- Intranasal Naloxone Repeat Dosing Strategies and Fentanyl Overdose: A Simulation-Based Randomized Clinical Trial.JAMA network open · 2024Trial
- A randomized clinical trial of the effects of brief versus extended opioid overdose education on naloxone utilization outcomes by individuals with opioid use disorder.Drug and alcohol dependence · 2022Trial
- Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection.Drug delivery and translational research · 2022Trial
- Predicting overdose among individuals prescribed opioids using routinely collected healthcare utilization data.PloS one · 2020Trial
- Fighting Fire with Fire: Development of Intranasal Nalmefene to Treat Synthetic Opioid Overdose.The Journal of pharmacology and experimental therapeutics · 2019Trial
- Effect of Intranasal vs Intramuscular Naloxone on Opioid Overdose: A Randomized Clinical Trial.JAMA network open · 2019Trial
- Trial
- Pharmacokinetics and -dynamics of intramuscular and intranasal naloxone: an explorative study in healthy volunteers.European journal of clinical pharmacology · 2018Trial
- Trial
- Incidence of Naloxone-Use Before and After Implementing Opioid Safety Measures for Patients Hospitalised on General Wards in a Swiss University Hospital.Drug safety · 2026Observational
- Elevated Cardiovascular Risk and Mortality in Type 2 Diabetes Mellitus Patients With Cannabis, Opioid, and Cocaine Use Disorders.Diabetes, obesity & metabolism · 2026Article
- A wearable acoustofluidic patch for rapid reversal of opioid overdose.Nature communications · 2026Article
- Opioid-specific risk of respiratory depression in non-cancer pain: a retrospective cohort study.BMC medicine · 2026Article
- Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
1 author.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.