Evidence map›Paper›PMID 22784110›Full record

ArticleMaternal & child nutrition2014

Maternal selenium, copper and zinc concentrations in pregnancy associated with small-for-gestational-age infants.

Hiten D Mistry, Lesia O Kurlak, Scott D Young, Annette L Briley, Fiona Broughton Pipkin, Philip N Baker, Lucilla Poston

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal & child nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  11. Genetic predicted causal inferences between antioxidants and birth weight.Journal of clinical biochemistry and nutrition · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hiten D MistryDivision of Women's Health, King's College London, Women's Health Academic Centre, KHP, London, UK Department of Obstetrics & Gynaecology, School of Clinical Sciences, University of Nottingham, Nottingham, UK School of Biosciences, Faculty of Science, University of Nottingham, Nottingham, UK Departments of Obstetrics/Gynecology & Physiology, University of Alberta, Edmonton, Alberta, Canada.
Lesia O Kurlak
Scott D Young
Annette L Briley
Fiona Broughton Pipkin
Philip N Baker
Lucilla Poston
University of Nottingham · GBKing's College London · GBUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy during adolescence increases the risk of adverse pregnancy outcome, especially small-for-gestational-age (SGA) birth, which has been linked to micronutrient deficiencies. Smoking has been shown to be related to lower micronutrient concentrations. Different ethnicities have not been examined. We used a subset from a prospective observational study, the About Teenage Eating study consisting of 126 pregnant adolescents (14-18-year-olds) between 28 and 32 weeks gestation. Micronutrient status was assessed by inductively coupled mass spectrometry. Smoking was assessed by self-report and plasma cotinine, and SGA was defined as infants born <10th corrected birthweight centile. The main outcome measures were as follows: (1) maternal plasma selenium, copper and zinc concentrations in adolescent mothers giving birth to SGA vs. appropriate-for-gestational-age (AGA) infants; and (2) comparison of micronutrient concentrations between women of different ethnicities and smoking habits. The plasma selenium {mean ± standard deviation (SD) [95% confidence interval (CI)]} concentration was lower in the SGA [n = 19: 49.4 ± 7.3 (CI: 45.9, 52.9) µg L(-1)] compared with the AGA [n = 107: 65.1 ± 12.5 (CI: 62.7, 67.5) µg L(-1); P < 0.0001] group. Smoking mothers had a lower selenium concentration compared with non-smokers (P = 0.01) and Afro-Caribbean women had higher selenium concentrations compared with White Europeans (P = 0.02). Neither copper nor zinc concentrations varied between groups. Low plasma selenium concentration in adolescent mothers could contribute to the risk of delivering an SGA infant, possibly through lowering placental antioxidant defence, thus directly affecting fetal growth. Differences in plasma selenium between ethnicities may relate to variation in nutritional intake, requiring further investigation.

Indexed as

Maternal Nutritional Physiological PhenomenaPregnancy OutcomeAdolescentBirth WeightCopperFemaleFetal DevelopmentGestational AgeHumansInfantInfant, Small for Gestational AgeMicronutrientsNutritional StatusObservational Studies as TopicPregnancySeleniumCopperMicronutrientsSeleniumZincadolescencemicronutrientssmall-for-gestational-age

Identifiers

PMID22784110
PMCPMC6860350
OpenAlexW1555296387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.