ArticleJournal of neurochemistry2012
NeuroD1 is required for survival of photoreceptors but not pinealocytes: results from targeted gene deletion studies.
Article in Journal of neurochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- New Insights on the Regulatory Gene Network Disturbed in Central Areolar Choroidal Dystrophy-Beyond Classical Gene Candidates.Frontiers in genetics · 2022Pooled it
- Recent progress of principal techniques used in the study of Müller glia reprogramming in mice.Cell regeneration (London, England) · 2024Review
- Overexpressing NeuroD1 reprograms Müller cells into various types of retinal neurons.Neural regeneration research · 2023Article
- Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development.Frontiers in molecular neuroscience · 2023Review
- Vision and retina evolution: How to develop a retina.IBRO neuroscience reports · 2022Article
- Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis.Scientific reports · 2020Article
- A New Cerkl Mouse Model Generated by CRISPR-Cas9 Shows Progressive Retinal Degeneration and Altered Morphological and Electrophysiological Phenotype.Investigative ophthalmology & visual science · 2020Article
- Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye.Stem cells and development · 2019Article
- Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs.Journal of molecular cell biology · 2019Article
- Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.Scientific reports · 2019Article
- Single Cell Sequencing of the Pineal Gland: The Next Chapter.Frontiers in endocrinology · 2019Review
- REforge Associates Transcription Factor Binding Site Divergence in Regulatory Elements with Phenotypic Differences between Species.Molecular biology and evolution · 2018Article
- Gene Expression Profiling of the Optic Nerve Head of Patients with Primary Open-Angle Glaucoma.Journal of ophthalmology · 2017Article
- GABAergic signaling in the rat pineal gland.Journal of pineal research · 2016Article
- Cellular Basis of Pineal Gland Development: Emerging Role of Microglia as Phenotype Regulator.PloS one · 2016Article
- Ophthalmological phenotype associated with homozygous null mutation in the NEUROD1 gene.Molecular vision · 2015Article
- A homozygous missense mutation in NEUROD1 is associated with nonsyndromic autosomal recessive retinitis pigmentosa.Investigative ophthalmology & visual science · 2014Article
- Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance.Neurochemical research · 2013Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
NeuroD1 encodes a basic helix-loop-helix transcription factor involved in the development of neural and endocrine structures, including the retina and pineal gland. To determine the effect of NeuroD1 knockout in these tissues, a Cre/loxP recombination strategy was used to target a NeuroD1 floxed gene and generate NeuroD1 conditional knockout (cKO) mice. Tissue specificity was conferred using Cre recombinase expressed under the control of the promoter of Crx, which is selectively expressed in the pineal gland and retina. At 2 months of age, NeuroD1 cKO retinas have a dramatic reduction in rod- and cone-driven electroretinograms and contain shortened and disorganized outer segments; by 4 months, NeuroD1 cKO retinas are devoid of photoreceptors. In contrast, the NeuroD1 cKO pineal gland appears histologically normal. Microarray analysis of 2-month-old NeuroD1 cKO retina and pineal gland identified a subset of genes that were affected 2-100-fold; in addition, a small group of genes exhibit altered differential night/day expression. Included in the down-regulated genes are Aipl1, which is necessary to prevent retinal degeneration, and Ankrd33, whose protein product is selectively expressed in the outer segments. These findings suggest that NeuroD1 may act through Aipl1 and other genes to maintain photoreceptor homeostasis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.