Evidence map›Paper›PMID 22783546›Full record

ArticleFrontiers in oncology2012

The role of mitochondria in yeast programmed cell death.

Nicoletta Guaragnella, Maša Zdralević, Lucia Antonacci, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  12. Review
  13. Antifungal Activity of ToAP2D Peptide AgainstFrontiers in bioengineering and biotechnology · 2021
    Article
  14. Article
  15. Article
  16. Cell Death in Evolutionary Transitions in Individuality.The Yale journal of biology and medicine · 2019
    Review
  17. Article
  18. Article
  19. Review
  20. Adaptive Response and Tolerance to Acetic Acid inFrontiers in microbiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicoletta GuaragnellaInstitute of Biomembranes and Bioenergetics, National Research Council of Italy, Bari, Italy.
Maša Zdralević
Lucia Antonacci
Salvatore Passarella
Ersilia Marra
Sergio Giannattasio
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian apoptosis and yeast programmed cell death (PCD) share a variety of features including reactive oxygen species production, protease activity and a major role played by mitochondria. In view of this, and of the distinctive characteristics differentiating yeast and multicellular organism PCD, the mitochondrial contribution to cell death in the genetically tractable yeast Saccharomyces cerevisiae has been intensively investigated. In this mini-review we report whether and how yeast mitochondrial function and proteins belonging to oxidative phosphorylation, protein trafficking into and out of mitochondria, and mitochondrial dynamics, play a role in PCD. Since in PCD many processes take place over time, emphasis will be placed on an experimental model based on acetic acid-induced PCD (AA-PCD) which has the unique feature of having been investigated as a function of time. As will be described there are at least two AA-PCD pathways each with a multifaceted role played by mitochondrial components, in particular by cytochrome c.

Indexed as

acetic acidcytochrome cintracellular signalingmitochondriaprogrammed cell deathprotein traffickingyeast

Identifiers

PMID22783546
PMCPMC3388595
OpenAlexW2146875556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.