ArticleArchives of plastic surgery2012
Keloid scarring: understanding the genetic basis, advances, and prospects.
Article in Archives of plastic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Silicone gel sheeting for treating keloid scars.The Cochrane database of systematic reviews · 2023Pooled it
- Silicone gel sheeting for treating hypertrophic scars.The Cochrane database of systematic reviews · 2021Pooled it
- The Role of Hyaluronan in Keloid and Hypertrophic Scar Pathogenesis and Treatment.Plastic surgery (Oakville, Ont.) · 2026Review
- Association of Keloid with Body Mass Index and Hypertension: A Retrospective Controlled Study.Aesthetic plastic surgery · 2025Article
- The Pathophysiology and Management of Pathologic Scarring-a Contemporary Review.Advances in wound care · 2025Review
- Revisiting roles of mast cells and neural cells in keloid: exploring their connection to disease activity.Frontiers in immunology · 2024Article
- Natural History of Keloids: A Sociodemographic Analysis Using Structured and Unstructured Data.Dermatology and therapy · 2024Article
- The effects of mechanical force on fibroblast behavior in cutaneous injury.Frontiers in surgery · 2023Review
- Scar Perception: A Comparison of African American and White Self-identified Patients.Plastic and reconstructive surgery. Global open · 2022Article
- Remarkable efficiency of surgical shave excision of keloids followed by intralesional injection of Bleomycin. A retrospective study of 314 cases.Dermatologic therapy · 2022Review
- Long non-coding RNA H19 aggravates keloid progression by upregulating SMAD family member 5 expression via miR-196b-5p.Bioengineered · 2022Article
- OMICS Approaches Evaluating Keloid and Hypertrophic Scars.International journal of inflammation · 2022Review
- Effectiveness of combined microfocused ultrasound with visualization and subdermal calcium hydroxyapatite injections for the management of brachial skin laxity.Journal of cosmetic dermatology · 2021Article
- Current Advances in Hypertrophic Scar and Keloid Management.Seminars in plastic surgery · 2021Review
- Risk of cancer development in patients with keloids.Scientific reports · 2021Observational
- Association of Leptin Receptor Gene Polymorphisms with Keloids in the Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.Molecular and cellular biochemistry · 2021Article
- The association between keloid and osteoporosis: real-world evidence.BMC musculoskeletal disorders · 2021Article
- Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid.Frontiers in cell and developmental biology · 2021Review
- Outcomes of Surgical Excision and High-Dose-Rate Brachytherapy for Earlobe Keloids.World journal of plastic surgery · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keloid disease is a fibroproliferative dermal tumor with an unknown etiology that occurs after a skin injury in genetically susceptible individuals. Increased familial aggregation, a higher prevalence in certain races, parallelism in identical twins, and alteration in gene expression all favor a remarkable genetic contribution to keloid pathology. It seems that the environment triggers the disease in genetically susceptible individuals. Several genes have been implicated in the etiology of keloid disease, but no single gene mutation has thus far been found to be responsible. Therefore, a combination of methods such as association, gene-gene interaction, epigenetics, linkage, gene expression, and protein analysis should be applied to determine keloid etiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.