ArticleFrontiers in microbiology2012
The Antimicrobial Defense of the Pacific Oyster, Crassostrea gigas. How Diversity may Compensate for Scarcity in the Regulation of Resident/Pathogenic Microflora.
Article in Frontiers in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 114 citations in OpenAlex.
- Potential of Antimicrobial Peptide Synergies for Combating Infectious Diseases in Aquaculture: A Review.Animals : an open access journal from MDPI · 2026Review
- Temperature Influences Antimicrobial Resistance and Virulence ofPathogens (Basel, Switzerland) · 2025Article
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- Article
- Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Antimicrobial Peptide Synergies for Fighting Infectious Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Functional Diversification of Oyster Big Defensins Generates Antimicrobial Specificity and Synergy against Members of the Microbiota.Marine drugs · 2022Article
- RGD-Labeled Hemocytes With High Migration Activity Display a Potential Immunomodulatory Role in the Pacific OysterFrontiers in immunology · 2022Article
- Exploring the Dynamic of Bacterial Communities in Manila Clam (Frontiers in microbiology · 2022Article
- Distinct microbiota assembly mechanisms revealed in different reconstruction stages during gut regeneration in the sea cucumber Apostichopus japonicus.MicrobiologyOpen · 2021Article
- Elevated seasonal temperature disrupts prooxidant-antioxidant homeostasis and promotes cellular apoptosis in the American oyster, Crassostrea virginica, in the Gulf of Mexico: a field study.Cell stress & chaperones · 2021Article
- Molting Alters the Microbiome, Immune Response, and Digestive Enzyme Activity in Mud Crab (mSystems · 2021Article
- Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean.PLoS pathogens · 2021Article
- Cellular Immune Response of an Endemic Lake Baikal Amphipod to Indigenous Pseudomonas sp.Marine biotechnology (New York, N.Y.) · 2021Article
- Virulence ofFrontiers in immunology · 2021Article
- Immunological Responses of Marine Bivalves to Contaminant Exposure: Contribution of the -Omics Approach.Frontiers in immunology · 2021Review
- Comparative genomic analysis of Vibrios yields insights into genes associated with virulence towards C. gigas larvae.BMC genomics · 2020Article
- Histopathological and Molecular Study of Pacific Oyster Tissues Provides Insights intoPathogens (Basel, Switzerland) · 2020Article
- (Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members.Frontiers in chemistry · 2020Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthy oysters are inhabited by abundant microbial communities that vary with environmental conditions and coexist with immunocompetent cells in the circulatory system. In Crassostrea gigas oysters, the antimicrobial response, which is believed to control pathogens and commensals, relies on potent oxygen-dependent reactions and on antimicrobial peptides/proteins (AMPs) produced at low concentrations by epithelial cells and/or circulating hemocytes. In non-diseased oysters, hemocytes express basal levels of defensins (Cg-Defs) and proline-rich peptides (Cg-Prps). When the bacterial load dramatically increases in oyster tissues, both AMP families are driven to sites of infection by major hemocyte movements, together with bactericidal permeability/increasing proteins (Cg-BPIs) and given forms of big defensins (Cg-BigDef), whose expression in hemocytes is induced by infection. Co-localization of AMPs at sites of infection could be determinant in limiting invasion as synergies take place between peptide families, a phenomenon which is potentiated by the considerable diversity of AMP sequences. Besides, diversity occurs at the level of oyster AMP mechanisms of action, which range from membrane lysis for Cg-BPI to inhibition of metabolic pathways for Cg-Defs. The combination of such different mechanisms of action may account for the synergistic activities observed and compensate for the low peptide concentrations in C. gigas cells and tissues. To overcome the oyster antimicrobial response, oyster pathogens have developed subtle mechanisms of resistance and evasion. Thus, some Vibrio strains pathogenic for oysters are equipped with AMP-sensing systems that trigger resistance. More generally, the known oyster pathogenic vibrios have evolved strategies to evade intracellular killing through phagocytosis and the associated oxidative burst.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.