ArticleFrontiers in physiology2012
Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Overview of Cardiac Arrhythmias and Treatment Strategies.Pharmaceuticals (Basel, Switzerland) · 2023Review
- The physics of heart rhythm disorders.Physics reports · 2022Article
- Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?Frontiers in physiology · 2022Review
- Cardiac Alternans Occurs through the Synergy of Voltage- and Calcium-Dependent Mechanisms.Membranes · 2021Article
- A Computational Study of the Effects of Tachycardia-Induced Remodeling on Calcium Wave Propagation in Rabbit Atrial Myocytes.Frontiers in physiology · 2021Article
- Key aspects for effective mathematical modelling of fractional-diffusion in cardiac electrophysiology: a quantitative study.Communications in nonlinear science & numerical simulation · 2020Article
- Cardiomyocyte-Specific STIM1 (Stromal Interaction Molecule 1) Depletion in the Adult Heart Promotes the Development of Arrhythmogenic Discordant Alternans.Circulation. Arrhythmia and electrophysiology · 2019Article
- β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: AnFrontiers in physiology · 2019Article
- Computational Modeling of Electrophysiology and Pharmacotherapy of Atrial Fibrillation: Recent Advances and Future Challenges.Frontiers in physiology · 2018Review
- Cardiac electrophysiological adaptations in the equine athlete-Restitution analysis of electrocardiographic features.PloS one · 2018Article
- Membrane potential determines calcium alternans through modulation of SR CaJournal of molecular and cellular cardiology · 2017Article
- Alternans in atria: Mechanisms and clinical relevance.Medicina (Kaunas, Lithuania) · 2017Review
- Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium.Scientific reports · 2016Article
- The mechanisms of calcium cycling and action potential dynamics in cardiac alternans.Circulation research · 2015Article
- Evolution of action potential alternans in rabbit heart during acute regional ischemia.BioMed research international · 2015Article
- Ion channels under the sun.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Calcium alternans in cardiac myocytes: order from disorder.Journal of molecular and cellular cardiology · 2013Review
- Formation of spatially discordant alternans due to fluctuations and diffusion of calcium.PloS one · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cardiac repolarization alternans is a rhythm disturbance of the heart in which rapid stimulation elicits a beat-to-beat alternation in the duration of action potentials and magnitude of intracellular calcium transients in individual cardiac myocytes. Although this phenomenon has been identified as a potential precursor to dangerous reentrant arrhythmias and sudden cardiac death, significant uncertainty remains regarding its mechanism and no clinically practical means of halting its occurrence or progression currently exists. Cardiac alternans has well-characterized tissue, cellular, and subcellular manifestations, the mechanisms and interplay of which are an active area of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.