ArticleFrontiers in cellular neuroscience2012
High temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampus.
Article in Frontiers in cellular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58 citing papers in PubMed, 126 citations in OpenAlex.
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- Sodium valproate and gabapentin reduce the seizure-like behavior induced by pentylenetetrazol and mechanical stress in Drosophila melanogaster: sex influence on behavioral responses.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Compensation of the effects of temperature on a motor system in the crab,bioRxiv : the preprint server for biology · 2026Article
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- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- Sleep-wake variation in body temperature regulates tau secretion and correlates with CSF and plasma tau.The Journal of clinical investigation · 2025Article
- Response of dorsal horn neurons in mice to high-frequency (kHz) biphasic stimulation is not sensitive to local temperature rise.Physiological reports · 2025Article
- A Flexible, Implantable, Bioelectronic Electroporation Device for Targeted Ablation of Seizure Foci in the Mouse Brain.Sensors (Basel, Switzerland) · 2024Article
- Review
- Sleep-wake body temperature regulates tau secretion in mice and correlates with CSF and plasma tau in humans.Research square · 2024Article
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- Thermal neuromodulation using pulsed and continuous infrared illumination in a penicillin-induced acute epilepsy model.Scientific reports · 2023Article
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- Thermal effects on neurons during stimulation of the brain.Journal of neural engineering · 2022Article
- Bidirectional modulation of evoked synaptic transmission by pulsed infrared light.Scientific reports · 2022Article
- Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization.Nature communications · 2022Article
- A dynamics model of neuron-astrocyte network accounting for febrile seizures.Cognitive neurodynamics · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Temperature has multiple effects on neurons, yet little is known about the effects of high temperature on the physiology of mammalian central neurons. Hyperthermia can influence behavior and cause febrile seizures. We studied the effects of acute hyperthermia on the immature hippocampus in vitro by recording from pyramidal neurons and inhibitory oriens-lacunosum moleculare (O-LM) interneurons (identified by green fluorescent protein (GFP) expression in the GIN mouse line). Warming to 41°C caused depolarization, spontaneous action potentials, reduced input resistance and membrane time constant, and increased spontaneous synaptic activity of most pyramidal cells and O-LM interneurons. Pyramidal neurons of area CA3 were more strongly excited by hyperthermia than those of area CA1. About 90% of O-LM interneurons in both CA1 and CA3 increased their firing rates at hyperthermic temperatures; interneurons in CA3 fired faster than those in CA1 on average. Blockade of fast synaptic transmission did not abolish the effect of hyperthermia on neuronal excitability. Our results suggest that hyperthermia increases hippocampal excitability, particularly in seizure-prone area CA3, by altering the intrinsic membrane properties of pyramidal cells and interneurons.
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