ArticleWorld journal of gastroenterology2012
Effect of biologically active fraction of Nardostachys jatamansi on cerulein-induced acute pancreatitis.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Desoxo-narchinol A and Narchinol B Isolated from Nardostachys jatamansi Exert Anti-neuroinflammatory Effects by Up-regulating of Nuclear Transcription Factor Erythroid-2-Related Factor 2/Heme Oxygenase-1 Signaling.Neurotoxicity research · 2019Article
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- Protective Effect of a Polyherbal Traditional Formula Consisting ofIranian journal of pharmaceutical research : IJPR · 2017Article
- Cytoprotective role of heme oxygenase-1 in liver ischemia reperfusion injury.International journal of clinical and experimental medicine · 2015Review
- Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: an answer from nature.World journal of gastroenterology · 2014Review
- Preventive Effect of Three Pomegranate (Punica granatum L.) Seeds Fractions on Cerulein-Induced Acute Pancreatitis in Mice.International journal of preventive medicine · 2014Article
- Beneficial Effects of Fractions of Nardostachys jatamansi on Lipopolysaccharide-Induced Inflammatory Response.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review.World journal of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine if the fraction of Nardostachys jatamansi (NJ) has the potential to ameliorate the severity of acute pancreatitis (AP).
methodsMice were administered the biologically active fraction of NJ, i.e., the 4th fraction (NJ4), intraperitoneally, and then injected with the stable cholecystokinin analogue cerulein hourly for 6 h. Six hours after the last cerulein injection, the pancreas, lung, and blood were harvested for morphological examination, measurement of cytokine expression, and examination of neutrophil infiltration.
resultsNJ4 administration attenuated the severity of AP and lung injury associated with AP. It also reduced cytokine production and neutrophil infiltration and resulted in the in vivo up-regulation of heme oxygenase-1 (HO-1). Furthermore, NJ4 and its biologically active fraction, NJ4-2 inhibited the cerulein-induced death of acinar cells by inducing HO-1 in isolated pancreatic acinar cells.
conclusionThese results suggest that NJ4 may be a candidate fraction offering protection in AP and NJ4 might ameliorate the severity of pancreatitis by inducing HO-1 expression.
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