ArticleParasitology research2012
Effects of the Chinese medicine matrine on experimental C. parvum infection in BALB/c mice and MDBK cells.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Mechanism of oxymatrine in the treatment of cryptosporidiosis through TNF/NF-κB signaling pathway based on network pharmacology and experimental validation.Scientific reports · 2024Article
- Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases.Frontiers in pharmacology · 2023Review
- Matrine reverses the drug resistance of K562/ADM cells to ADM and VCR via promoting autophagy.Translational cancer research · 2020Article
- Matrine suppresses breast cancer metastasis by targeting ITGB1 and inhibiting epithelial-to-mesenchymal transition.Experimental and therapeutic medicine · 2020Article
- Therapeutic and immunoregulatory effects of water-soluble alkaloids E2-a from Sophora moorcroftiana seeds as a novel potential agent against echinococcosis in experimentally protoscolex-infected mice.Veterinary research · 2018Article
- Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/β-catenin signaling pathway.Experimental and therapeutic medicine · 2014Article
- Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.Antimicrobial agents and chemotherapy · 2014Article
- Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-κB signaling pathway.Oncology letters · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, there are no effective methods of treating Cryptosporidium infection in animals or humans. Matrine, a main active alkaloid extract from Sophora flavescens, has potential antineoplastic, antifibrotic, anti-inflammatory, and antitumor activities. However, the treating effects of matrine on Cryptosporidium infection as well as its mechanisms of action are largely unknown. The present study investigated the effects of matrine on Cryptosporidium parvum infection in both in vitro and in vivo models. Oocyst excretion, plasma D-lactic acid concentrations, and bacterial translocation rates were assayed to evaluate the efficacy of treatment in experimentally infected BALB/c mice. Matrine effects on parasite replication and lactate dehydrogenase (LDH) activity were assessed in cell cultures. The results showed that matrine could significantly reduce the number of C. parvum oocysts by 54-63%, and the number of C. parvum-infected cells by 28-58%. Plasma D-lactic acid concentrations and LDH activity in the matrine-treated groups were lower than the infected group (P < 0.05) and higher than the control (P < 0.05). The bacterial translocation rates in groups treated with matrine at high doses were lower than the infected group (P < 0.05) and not higher than the control (P > 0.05). These results clearly demonstrate that matrine can inhibit C. parvum infection. Integrity of cell membranes and of the mucosal barrier is improved in treated animals as compared to untreated infected controls. Thus, it is concluded that matrine has a potential in therapeutic applications against C. parvum infection.
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