Evidence map›Paper›PMID 22782111›Full record

ReviewCellular and molecular life sciences : CMLS2013

Monoamine oxidases in development.

Chi Chiu Wang, Ellen Billett, Astrid Borchert, Hartmut Kuhn, Christoph Ufer

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Type A monoamine oxidase; its unique role in mood, behavior and neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. PET imaging of reactive astrocytes in neurological disorders.European journal of nuclear medicine and molecular imaging · 2022
    Review
  14. Detection and relative quantification of amine oxidase gene (Journal of food science and technology · 2022
    Article
  15. Article
  16. Article
  17. Ciproxifan, a histamine HScientific reports · 2017
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Chi Chiu WangDepartment of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong.
Ellen Billett
Astrid Borchert
Hartmut Kuhn
Christoph Ufer
Charité - Universitätsmedizin Berlin · DEChinese University of Hong Kong · CNNottingham Trent University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoamine oxidases (MAOs) are flavoproteins of the outer mitochondrial membrane that catalyze the oxidative deamination of biogenic and xenobiotic amines. In mammals there are two isoforms (MAO-A and MAO-B) that can be distinguished on the basis of their substrate specificity and their sensitivity towards specific inhibitors. Both isoforms are expressed in most tissues, but their expression in the central nervous system and their ability to metabolize monoaminergic neurotransmitters have focused MAO research on the functionality of the mature brain. MAO activities have been related to neurodegenerative diseases as well as to neurological and psychiatric disorders. More recently evidence has been accumulating indicating that MAO isoforms are expressed not only in adult mammals, but also before birth, and that defective MAO expression induces developmental abnormalities in particular of the brain. This review is aimed at summarizing and critically evaluating the new findings on the developmental functions of MAO isoforms during embryogenesis.

Indexed as

Gene Expression Regulation, DevelopmentalAmino Acid SequenceAnimalsDrug DiscoveryHumansModels, MolecularMolecular Sequence DataMonoamine OxidaseMonoamine Oxidase InhibitorsProtein IsoformsSequence AlignmentMonoamine OxidaseMonoamine Oxidase InhibitorsProtein Isoforms

Identifiers

PMID22782111
PMCPMC11113580
OpenAlexW2059820434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.