ArticleDevelopment and psychopathology2012
Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: the example of alcohol use promoting peers and μ-opioid receptor M1 variation.
Article in Development and psychopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Parental Substance Use Modeling and Monthly Alcohol, Cannabis, and E-Cigarette Use Among Female Adolescents and Young Adults.Translational issues in psychological science · 2026Article
- Sex Difference in Effect of the OPRM1 Gene A118G (rs1799971) Single-Nucleotide Polymorphism on the Requirement for Postoperative Fentanyl in Japanese Patients Who Underwent Laparoscopic-Assisted Colectomy.Neuropsychopharmacology reports · 2026Article
- A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.The American journal on addictions · 2018Review
- Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk.Development and psychopathology · 2018Article
- Interaction Between the μ-Opioid Receptor Gene and the Number of Heavy-Drinking Peers on Alcohol Use.Alcoholism, clinical and experimental research · 2017Article
- ALDH2*2 and peer drinking in East Asian college students.The American journal of drug and alcohol abuse · 2017Article
- The interaction between the dopamine receptor D4 (DRD4) variable number tandem repeat polymorphism and perceived peer drinking norms in adolescent alcohol use and misuse.Development and psychopathology · 2017Article
- Parent and peer influences on emerging adult substance use disorder: A genetically informed study.Development and psychopathology · 2017Article
- Testing the Relations Among Family Disorganization, Delay Discounting, and Adolescent Alcohol Use: A Genetically Informed Study.Alcoholism, clinical and experimental research · 2016Article
- Social network drinking and family history contribute equally to first-onset alcohol dependence in high risk adults.Drug and alcohol dependence · 2014Article
- Maturing out of alcohol involvement: transitions in latent drinking statuses from late adolescence to adulthood.Development and psychopathology · 2013Article
- The developmental psychopathology of alcohol use and alcohol disorders: research achievements and future directions.Development and psychopathology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
This study examined the interplay between the influence of peers who promote alcohol use and μ-opioid receptor M1 (OPRM1) genetic variation in the intergenerational transmission of alcohol use disorder (AUD) symptoms while separating the "traitlike" components of AUD symptoms from their age-specific manifestations at three ages from emerging adulthood (17-23 years) to adulthood (29-40 years). The results for males were consistent with genetically influenced peer selection mechanisms as mediators of parent alcoholism effects. Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages. There was evidence for women of an interaction between OPRM1 variation and peer affiliations but only at the earliest age band. Peer influences had stronger effects among women who were G-carriers. These results illustrate the complex ways in which the interplay between influences at multiple levels of analysis can underlie the intergenerational transmission of alcohol disorders as well as the importance of considering age and gender differences in these pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.