ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Developmental mediation of genetic variation in response to the Fast Track prevention program.Development and psychopathology · 2015Trial
- Effects of prenatal exposure to the 1944-45 Dutch famine and glucocorticoid receptor polymorphisms on later life PTSD susceptibility.European journal of psychotraumatology · 2023Article
- Differential Diagnosis of Major Depressive Disorder and Bipolar Disorder: Genetic and Hormonal Assessment and the Influence of Early-Life Stress.Brain sciences · 2022Article
- Maternal early exposure to violence, psychopathology, and child adaptive functioning: pre- and postnatal programming.Pediatric research · 2022Article
- A common clinical conundrum: Antidepressant treatment of depression in pregnant women.Seminars in perinatology · 2020Review
- Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood.Clinical epigenetics · 2019Article
- Associations of Prenatal and Postnatal Maternal Depressive Symptoms with Offspring Cognition and Behavior in Mid-Childhood: A Prospective Cohort Study.International journal of environmental research and public health · 2019Article
- Prenatal Maternal Distress: A Risk Factor for Child Anxiety?Clinical child and family psychology review · 2018Review
- Annual Research Review: Early adversity, the hypothalamic-pituitary-adrenocortical axis, and child psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2018Review
- Prenatal Maternal Stress and the Risk of Asthma in Children.Frontiers in pediatrics · 2017Review
- The Association of Neighborhood Gene-Environment Susceptibility with Cortisol and Blood Pressure in African-American Adults.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016Article
- Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management] · 2015Article
- The Generation R Study: Biobank update 2015.European journal of epidemiology · 2014Article
- The relationship between glucocorticoid receptor polymorphisms, stressful life events, social support, and post-traumatic stress disorder.BMC psychiatry · 2014Article
- Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy.BioMed research international · 2014Article
- An interaction of a NR3C1 polymorphism and antenatal solar activity impacts both hippocampus volume and neuroticism in adulthood.Frontiers in human neuroscience · 2013Article
- Association between genetic variants and depression in a Romanian cohort.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal maternal psychopathology affects child development, but some children seem more vulnerable than others. Genetic variance in hypothalamic-pituitary-adrenal axis genes may influence the effect of prenatal maternal psychological symptoms on child emotional and behavioral problems. This hypothesis was tested in the Generation R Study, a population-based cohort from fetal life onward. In total, 1727 children of Northern European descent and their mothers participated in this study and were genotyped for variants in the glucocorticoid receptor (GR) gene (rs6189/rs6190, rs10052957, rs41423247, rs6195, and rs6198) and the FK506-binding protein 5 (FKBP5) gene (rs1360780). Prenatal maternal psychological symptoms were assessed at 20 weeks pregnancy and child behavior was assessed by both parents at 3 years. In a subsample of 331 children, data about cortisol reactivity were available. Based on power calculations, only those genetic variants with sufficient minor allele frequencies (rs41423247, rs10052957, and rs1360780) were included in the interaction analyses. We found that variation in GR at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child emotional and behavioral problems (beta 0.41, SE 0.16, p=0.009). This prenatal interaction effect was independent of mother's genotype and maternal postnatal psychopathology, and not found for prenatal psychological symptoms of the father. Moreover, the interaction between rs41423247 and prenatal psychological symptoms was also associated with decreased child cortisol reactivity (beta -2.30, p-value 0.05). These findings emphasize the potential effect of prenatal gene-environment interaction, and give insight in possible mechanisms accounting for children's individual vulnerability to develop emotional and behavioral problems.
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