Evidence map›Paper›PMID 22781556›Full record

ReviewJournal of investigative medicine : the official publication of the American Federation for Clinical Research2012

Views of translational research from a somewhat translational scientist.

William T Talman

Abstract readReview
In one paragraph

Review in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

William T TalmanLaboratory of Neurobiology, Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. william-talman@uiowa.edu

Funding

Neurogenic Cardiac Damage and Sudden DeathR01HL088090 · NHLBI · UNIVERSITY OF IOWA · PI LIN, LI-HSIEN, TALMAN, WILLIAM TEMPLE · 2008 to 2011
$1.5M
CARDIOVASCULAR RESPONSE TO GLUTAMATE NITRIC OXIDER01HL059593 · NHLBI · UNIVERSITY OF IOWA · PI TALMAN, WILLIAM TEMPLE · 1999 to 2006
$1.4M
AFMR-Translational Medical Research Symposia SeriesR13RR023236 · NCRR · AMERICAN FEDERATION FOR MEDICAL RESEARCH · PI ZUCKER, DEBORAH R · 2006 to 2010
$263k
NCRR NIH HHS R13 RR023236NHLBI NIH HHS R01 HL059593NHLBI NIH HHS R01 HL 088090NHLBI NIH HHS R01 HL088090NHLBI NIH HHS R01 HL 59593
6 · The paper itself

Abstract

This review arose from a talk entitled "Identifying Targets" and given by the author at EB2011 at the invitation of the American Federation for Medical Research (AFMR). The presentation was part of the American Federation for Medical Research workshop entitled "Keys for Translation: Science and Strategy" and focused on identifying clinically relevant targets as a result of observations made during basic scientific studies. The review emphasizes that targets do not have to be the aim that drives basic discovery, but communication between the basic scientist and clinical investigators may aid recognition of such targets and their translation to clinical applications. Using one line of investigator-initiated research from his own laboratory as an example, the author emphasizes that basic discovery must be hypothesis driven and allowed to follow its logical sequence. Finding treatments, while always an aim of biomedical research, may arise as a result of basic studies that were not originally aimed at a target of translational research.

Indexed as

Research PersonnelTranslational Research, BiomedicalAnimalsHumansSolitary Nucleus

Identifiers

PMID22781556
PMCPMC4337401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.