Evidence map›Paper›PMID 22780329›Full record

ReviewNeuromodulation : journal of the International Neuromodulation Society2012

Translational neuromodulation: approximating human transcranial magnetic stimulation protocols in rats.

Andrew M Vahabzadeh-Hagh, Paul A Muller, Roman Gersner, Abraham Zangen, Alexander Rotenberg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuromodulation : journal of the International Neuromodulation Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew M Vahabzadeh-HaghDepartment of Neurology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Paul A Muller
Roman Gersner
Abraham Zangen
Alexander Rotenberg

Funding

Antiepileptogenesis by Transcranial Magnetic StimulationK08NS055895 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ROTENBERG, ALEXANDER · 2007 to 2011
$867k
Howard Hughes Medical InstituteNINDS NIH HHS K08 NS055895NINDS NIH HHS K08NS055895
6 · The paper itself

Abstract

objectiveTranscranial magnetic stimulation (TMS) is a well-established clinical protocol with numerous potential therapeutic and diagnostic applications. Yet, much work remains in the elucidation of TMS mechanisms, optimization of protocols, and in development of novel therapeutic applications. As with many technologies, the key to these issues lies in the proper experimentation and translation of TMS methods to animal models, among which rat models have proven popular. A significant increase in the number of rat TMS publications has necessitated analysis of their relevance to human work. We therefore review the essential principles for the approximation of human TMS protocols in rats as well as specific methods that addressed these issues in published studies. MATERIALS AND

methodsWe performed an English language literature search combined with our own experience and data. We address issues that we see as important in the translation of human TMS methods to rat models and provide a summary of key accomplishments in these areas.

resultsAn extensive literature review illustrated the growth of rodent TMS studies in recent years. Current advances in the translation of single, paired-pulse, and repetitive stimulation paradigms to rodent models are presented. The importance of TMS in the generation of data for preclinical trials is also highlighted.

conclusionsRat TMS has several limitations when considering parallels between animal and human stimulation. However, it has proven to be a useful tool in the field of translational brain stimulation and will likely continue to aid in the design and implementation of stimulation protocols for therapeutic and diagnostic applications.

Indexed as

AnesthesiaAnimalsEvoked Potentials, MotorHumansRatsResearch DesignSpecies SpecificityTranscranial Magnetic StimulationTranslational Research, Biomedical

Identifiers

PMID22780329
PMCPMC5764706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.