ArticleAddiction biology2013
Genome-wide association study of a quantitative disordered gambling trait.
Article in Addiction biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 107 citations in OpenAlex.
- Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children.Addiction (Abingdon, England) · 2025Article
- Biochemical Diagnosis in Substance and Non-substance Addiction.Advances in experimental medicine and biology · 2025Review
- Similarities and Differences in Genetics.Advances in experimental medicine and biology · 2025Review
- Genetics of gambling disorder and related phenotypes: The potential uses of polygenic and multifactorial risk models to enable early detection and improve clinical outcomes.Journal of behavioral addictions · 2024Article
- Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans.International journal of molecular sciences · 2024Article
- Differential transcriptome profile underlying risky choice in a rat gambling task.Journal of behavioral addictions · 2022Article
- The role of neurotrophin genes involved in the vulnerability to gambling disorder.Scientific reports · 2022Article
- FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors.Journal of personalized medicine · 2022Article
- Predicting disordered gambling across adolescence and young adulthood from polygenic contributions to Big 5 personality traits in a UK birth cohort.Addiction (Abingdon, England) · 2022Article
- Genetic and environmental influences on gambling disorder liability: a replication and combined analysis of two twin studies.Psychological medicine · 2019Article
- Dopamine and Gambling Disorder: Prospects for Personalized Treatment.Current addiction reports · 2019Article
- Alcohol use, psychiatric disorders and gambling behaviors: A multi-sample study testing causal relationships via the co-twin control design.Addictive behaviors · 2019Article
- Potential Causal Influence of Neighborhood Disadvantage on Disordered Gambling: Evidence From a Multilevel Discordant Twin Design.Clinical psychological science : a journal of the Association for Psychological Science · 2019Article
- Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.Biological psychiatry · 2018Article
- Behavioral Addictions as Mental Disorders: To Be or Not To Be?Annual review of clinical psychology · 2018Review
- Clinical neuropsychiatric considerations regarding nonsubstance or behavioral addictions.Dialogues in clinical neuroscience · 2017Review
- Gambling disorder: an integrative review of animal and human studies.Annals of the New York Academy of Sciences · 2017Review
- A Preliminary Study of DBH (Encoding Dopamine Beta-Hydroxylase) Genetic Variation and Neural Correlates of Emotional and Motivational Processing in Individuals With and Without Pathological Gambling.Journal of behavioral addictions · 2016Article
- Behavioral addictions in addiction medicine: from mechanisms to practical considerations.Progress in brain research · 2016Review
- Addiction-related genes in gambling disorders: new insights from parallel human and pre-clinical models.Molecular psychiatry · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Disordered gambling is a moderately heritable trait, but the underlying genetic basis is largely unknown. We performed a genome-wide association study (GWAS) for disordered gambling using a quantitative factor score in 1312 twins from 894 Australian families. Association was conducted for 2 381 914 single-nucleotide polymorphisms (SNPs) using the family-based association test in Merlin followed by gene and pathway enrichment analyses. Although no SNP reached genome-wide significance, six achieved P-values < 1 × 10(-5) with variants in three genes (MT1X, ATXN1 and VLDLR) implicated in disordered gambling. Secondary case-control analyses found two SNPs on chromosome 9 (rs1106076 and rs12305135 near VLDLR) and rs10812227 near FZD10 on chromosome 12 to be significantly associated with lifetime Diagnostic and Statistical Manual of Mental Disorders, fourth edition pathological gambling and South Oaks Gambling Screen classified probable pathological gambling status. Furthermore, several addiction-related pathways were enriched for SNPs associated with disordered gambling. Finally, gene-based analysis of 24 candidate genes for dopamine agonist-induced gambling in individuals with Parkinson's disease suggested an enrichment of SNPs associated with disordered gambling. We report the first GWAS of disordered gambling. While further replication is required, the identification of susceptibility loci and biological pathways will be important in characterizing the biological mechanisms that underpin disordered gambling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.