ArticleThe Journal of chemical physics2012
On the origin of the unusual behavior in the stretching of single-stranded DNA.
Article in The Journal of chemical physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Computational Modeling of DNA 3D Structures: From Dynamics and Mechanics to Folding.Molecules (Basel, Switzerland) · 2023Review
- Ab initio predictions for 3D structure and stability of single- and double-stranded DNAs in ion solutions.PLoS computational biology · 2022Article
- Structure, stability and specificity of the binding of ssDNA and ssRNA with proteins.PLoS computational biology · 2019Article
- Quantitative determination of the spring entropy effect and its indication of the conformational change of polymer coils with varying concentration in aqueous poly(RSC advances · 2019Article
- Sequence-Dependent Three Interaction Site Model for Single- and Double-Stranded DNA.Journal of chemical theory and computation · 2018Article
- Visualizing single-stranded nucleic acids in solution.Nucleic acids research · 2017Article
- Single-stranded nucleic acid elasticity arises from internal electrostatic tension.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The impact of base stacking on the conformations and electrostatics of single-stranded DNA.Nucleic acids research · 2017Article
- Sequence-dependent elasticity and electrostatics of single-stranded DNA: signatures of base-stacking.Biophysical journal · 2014Article
- The snakelike chain character of unstructured RNA.Biophysical journal · 2013Article
- Global force-torque phase diagram for the DNA double helix: structural transitions, triple points, and collapsed plectonemes.Physical review. E, Statistical, nonlinear, and soft matter physics · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Force-extension curves (FECs), which quantify the response of a variety of biomolecules subject to mechanical force (f), are often quantitatively fit using worm-like chain (WLC) or freely jointed chain (FJC) models. These models predict that the chain extension, x, normalized by the contour length increases linearly at small f and at high forces scale as x ~ (1 - f(-α)), where α = 0.5 for WLC and unity for FJC. In contrast, experiments on single-stranded DNA (ssDNA) show that over a range of f and ionic concentration, x scales as x ~ ln f, which cannot be explained using WLC or FJC models. Using theory and simulations we show that this unusual behavior in FEC in ssDNA is due to sequence-independent polyelectrolyte effects. We show that the x ~ ln f arises because in the absence of force the tangent correlation function, quantifying chain persistence, decays algebraically on length scales on the order of the Debye length. Our theory, which is most appropriate for monovalent salts, quantitatively fits the experimental data and further predicts that such a regime is not discernible in double-stranded DNA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.