ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2012
Integrative analysis of common neurodegenerative diseases using gene association, interaction networks and mRNA expression data.
Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth.Human molecular genetics · 2016Pooled it
- DNA methylation as a mediator of genetic and environmental influences on Parkinson's disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome.Frontiers in genetics · 2022Review
- Shared mechanisms among neurodegenerative diseases: from genetic factors to gene networks.Journal of genetics · 2018Review
- Integrated microRNA and mRNA network analysis of the human myometrial transcriptome in the transition from quiescence to labor.Biology of reproduction · 2018Article
- From Genomics to Omics Landscapes of Parkinson's Disease: Revealing the Molecular Mechanisms.Omics : a journal of integrative biology · 2018Article
- Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Knowledge-based compact disease models identify new molecular players contributing to early-stage Alzheimer's disease.BMC systems biology · 2013Article
- Article
- Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data.BMC systems biology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Alzheimer's and Parkinson's diseases (AD and PD) are two common neurodegenerative diseases primarily affecting memory and motor functions, respectively. In this study, we integrated data from various sources, and took a systems-biology approach to compare and contrast the molecular and network based dysregulation associated with AD and PD and we integrated these data with known pathways of drug treatment. First, we identified genes that exhibit consistent prior evidence of association with each disease. Then, we extracted disease-specific sub-networks from a human interactome database using associated genes as seeds. To rank the sub-networks we used existing gene expression data from cases and controls. Comparison of resulting disease-associated genes and networks revealed significant overlap between AD and PD. In addition, the identified sub-networks correlated with known drug interdiction pathways, and suggested new potential targets for intervention.
Identifiers
22779053PMC3392058What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.