ArticleEvidence-based complementary and alternative medicine : eCAM2012
Application of metabolomics in traditional chinese medicine differentiation of deficiency and excess syndromes in patients with diabetes mellitus.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Lung Tissue Metabolome Investigation Reveals the In Vivo Effects of Zhuye Shigao Decoction in an LPS-Induced Acute Pneumonia Model in Mice.Mediators of inflammation · 2026Article
- Investigation on Phenomics of Traditional Chinese Medicine from the Diabetes.Phenomics (Cham, Switzerland) · 2024Review
- Applying GC-MS based serum metabolomic profiling to characterize two traditional Chinese medicine subtypes of diabetic foot gangrene.Frontiers in molecular biosciences · 2024Article
- Genome wide identification and characterization of fertility associated novel CircRNAs as ceRNA reveal their regulatory roles in sheep fecundity.Journal of ovarian research · 2023Article
- Serum metabolomics analysis of deficiency pattern and excess pattern in patients with rheumatoid arthritis.Chinese medicine · 2022Article
- Human serum metabolomic analysis reveals progression for high blood pressure in type 2 diabetes mellitus.BMJ open diabetes research & care · 2021Article
- Emerging Applications of Metabolomics to Assess the Efficacy of Traditional Chinese Medicines for Treating Type 2 Diabetes Mellitus.Frontiers in pharmacology · 2021Review
- Identification of Characteristic Autoantibodies Associated With Deficiency Pattern in Traditional Chinese Medicine of Rheumatoid Arthritis Using Protein Chips.Frontiers in pharmacology · 2019Article
- Metabonomics onEmerging microbes & infections · 2019Article
- Application of variable selection in the origin discrimination of Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb. based on near infrared spectroscopy.Scientific reports · 2018Article
- Compound Fuling Granule Suppresses Ovarian Cancer Development and Progression by disrupting mitochondrial function, galactose and fatty acid metabolism.Journal of Cancer · 2018Article
- A metabolomics approach to stratify patients diagnosed with diabetes mellitus into excess or deficiency syndromes.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- NMR-Based Metabonomic Studies on Stomach Heat and Cold Syndromes and Intervention Effects of the Corresponding Formulas.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- An acupuncture research protocol developed from historical writings by mathematical reflections: a rational individualized acupoint selection method for immediate pain relief.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Towards polypharmacokinetics: pharmacokinetics of multicomponent drugs and herbal medicines using a metabolomics approach.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- ZHENG-Omics Application in ZHENG Classification and Treatment: Chinese Personalized Medicine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Differences in metabolites of different tongue coatings in patients with chronic hepatitis B.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Differences of excess and deficiency zheng in patients with chronic hepatitis B by urinary metabonomics.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Clinical Applications of Omics Technologies on ZHENG Differentiation Research in Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Recent highlights of metabolomics in chinese medicine syndrome research.Evidence-based complementary and alternative medicine : eCAM · 2013Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic profiling is widely used as a probe in diagnosing diseases. In this study, the metabolic profiling of urinary carbohydrates was investigated using gas chromatography/mass spectrometry (GC/MS) and multivariate statistical analysis. The kernel-based orthogonal projections to latent structures (K-OPLS) model were established and validated to distinguish between subjects with and without diabetes mellitus (DM). The model was combined with subwindow permutation analysis (SPA) in order to extract novel biomarker information. Furthermore, the K-OPLS model visually represented the alterations in urinary carbohydrate profiles of excess and deficiency syndromes in patients with diabetes. The combination of GC/MS and K-OPLS/SPA analysis allowed the urinary carbohydrate metabolic characterization of DM patients with different traditional Chinese medicine (TCM) syndromes, including biomarkers different from non-DM patients. The method presented in this study might be a complement or an alternative to TCM syndrome research.
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