ArticleExperimental diabetes research2012
Neonatally induced mild diabetes in rats and its effect on maternal, placental, and fetal parameters.
Article in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- High TXNIP expression accelerates the migration and invasion of the GDM placenta trophoblast.BMC pregnancy and childbirth · 2023Article
- Benefits of Vitamin D Supplementation on Pregnancy of Rats with Pregestational Diabetes and Their Offspring.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Effect of swimming exercise, insulin-associated or not, on inflammatory cytokines, apoptosis, and collagen in diabetic rat placentas.Histochemistry and cell biology · 2022Article
- A treatment with a boiled aqueous extract of Hancornia speciosa Gomes leaves improves the metabolic status of streptozotocin-induced diabetic rats.BMC complementary medicine and therapies · 2020Article
- Article
- Mild diabetes: long-term effects on gastric motility evaluated in rats.International journal of experimental pathology · 2018Article
- Increased O-Linked N-Acetylglucosamine Modification of NF-ΚB and Augmented Cytokine Production in the Placentas from Hyperglycemic Rats.Inflammation · 2017Article
- Beneficial effects of Hibiscus rosa-sinensis L. flower aqueous extract in pregnant rats with diabetes.PloS one · 2017Article
- Extracellular HSP70 levels in diabetic environment in rats.Cell stress & chaperones · 2015Article
- Histopathological, Ultrastructural and Apoptotic Changes in Diabetic Rat Placenta.Balkan medical journal · 2015Article
- Oxidative stress status and placental implications in diabetic rats undergoing swimming exercise after embryonic implantation.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Oxidative Stress in Maternal Blood and Placenta From Mild Diabetic Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Streptozotocin-induced diabetes models: pathophysiological mechanisms and fetal outcomes.BioMed research international · 2014Review
- Neonatally induced mild diabetes: influence on development, behavior and reproductive function of female Wistar rats.Diabetology & metabolic syndrome · 2013Article
- Mild diabetes models and their maternal-fetal repercussions.Journal of diabetes research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.