ArticleTheScientificWorldJournal2012
Ki-67 and MCM-2 in dental follicle and odontogenic cysts: the effects of inflammation on proliferative markers.
Article in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Biological mechanisms underlying the inflammatory radicular cyst formation-focus on epithelial proliferation: a systematic review of experimental cell and tissue models.Restorative dentistry & endodontics · 2026Article
- The Enigmatic Odontogenic Keratocyst: A Cross-sectional Study of Odontogenic Cysts and Tumors Using Ki-67.Rambam Maimonides medical journal · 2025Article
- Immunohistochemical Analysis of Dentigerous Cysts and Odontogenic Keratocysts Associated with Impacted Third Molars-A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Management of radicular cyst associated with primary teeth using decompression: a retrospective study.BMC oral health · 2022Article
- Comparative Metabolomics Reveals the Microenvironment of Common T-Helper Cells and Differential Immune Cells Linked to Unique Periapical Lesions.Frontiers in immunology · 2021Article
- Computerized Evaluation of the Immunoexpression of Ki-67 Protein in Odontogenic Keratocyst and Dentigerous Cyst.Head and neck pathology · 2020Article
- Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin.Clinical oral investigations · 2019Article
- P53 Protein Expression in Dental Follicle, Dentigerous Cyst, Odontogenic Keratocyst, and Inflammatory Subtypes of Cysts: An Immunohistochemical Study.Oman medical journal · 2017Article
- Mucous Cell Prosoplasia in Oral Pathologies: A Brief Review.Journal of clinical and diagnostic research : JCDR · 2017Review
- P63 and Ki-67 Expression in Dentigerous Cyst and Ameloblastomas.Journal of dentistry (Shiraz, Iran) · 2015Article
- A comparative study of PCNA and Ki-67 expression in dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma.International journal of molecular and cellular medicine · 2013Article
- Proliferative potential of impacted tooth lesions using Ki67 labelling index-A clinicopathological insight.National journal of maxillofacial surgeryArticle
- Proliferative and anti-apoptotic indices of unicystic ameloblastoma, odontogenic keratocyst, dentigerous cyst and radicular cyst.Journal of oral and maxillofacial pathology : JOMFPArticle
- P63 and Ki-67 expression in radicular cyst.Journal of oral biology and craniofacial researchArticle
- MCM3 and Ki67 proliferation markers in odontogenic cysts and ameloblastoma.Journal of oral biology and craniofacial researchArticle
- Discrepancy in diagnosis and characteristics of odontogenic cystic lesions in mixed dentition period; a retrospective study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate whether there is any association between inflammation and the expression of markers of cell cycle entry (Ki-67 and MCM-2) in dental follicle (DF) of asymptomatic impacted teeth and odontogenic cysts. The study consisted of 70 DFs and 20 odontogenic cysts (radicular cyst (RC), dentigerous cyst (DC) and keratocytic odontogenic tumor (KCOT) located at posterior mandibular region. Histological findings of inflammation for all specimen and mucous cell prosoplasia, squamous metaplasia, glandular epithelium for all DFs were stained with hematoxyline and eosin, periodic acid schiff, alcian blue, and mucin. Epithelial cell proliferation was determined by using immunohistochemical labeling for Ki-67 and MCM-2. The histologic examinations showed 16% mucous cell prosoplasia, 54% squamous metaplasia, 20% glandular epithelium, 37% inflammation. Inflammation was detected in all RCs and %62 in DF, %43 in DC and KCOT. Positive correlation was found between the inflammation of DF and odontogenic cysts (P < 0.01). The mean Ki-67 and MCM-2 expressions were found 9, 64 ± 5, 99 and 6, 34 ± 3, 81 in DF, 11, 85 ± 9, 01 and 13, 6 ± 9, 94 in odontogenic cysts, respectively. While the mean Ki-67 expressions were statistically significant in DF and KCOT (P < 0.01), MCM-2 were significant in RC and KCOT (P < 0.01). MCM-2 expresion in RCs were statistically significant than KCOT (P < 0.01). The results of this study indicated that the higher MCM-2 expressions in RC than the KCOT might be related to the inflammation and this protein might be more sensitive to inflammation.
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