ArticleSensors (Basel, Switzerland)2012
A fast response highly selective probe for the detection of glutathione in human blood plasma.
Article in Sensors (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation.Frontiers in molecular neuroscience · 2023Review
- Fluorescent Probes with Multiple Binding Sites for the Discrimination of Cys, Hcy, and GSH.Angewandte Chemie (International ed. in English) · 2017Review
- pH-Dependent Fluorescent Probe That Can Be Tuned for Cysteine or Homocysteine.Organic letters · 2017Article
- A minimalist fluorescent probe for differentiating Cys, Hcy and GSH in live cells.Chemical science · 2016Article
- A simple assay for glutathione in whole blood.The Analyst · 2015Article
- Differences in heterocycle basicity distinguish homocysteine from cysteine using aldehyde-bearing fluorophores.Chemical communications (Cambridge, England) · 2014Article
- A dual emission fluorescent probe enables simultaneous detection of glutathione and cysteine/homocysteine.Chemical science · 2014Article
- A selective glutathione probe based on AIE fluorogen and its application in enzymatic activity assay.Scientific reports · 2014Article
- Fluorescent probes based on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging.Chemistry (Weinheim an der Bergstrasse, Germany) · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A fluorescent probe for glutathione (GSH) detection was developed. Our study indicates a possible mechanism which couples a conjugate addition and micelle-catalyzed large membered ring formation/elimination sequence. This method enables excellent selectivity towards GSH over other biological thiols such as cysteine (Cys) and homocysteine (Hcy). The proposed method is precise with a relative standard deviation (R.S.D) lower than 6% (n = 3) and has been successfully applied to determine GSH in human plasma with recoveries between 99.2% and 102.3%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.