ArticleInfectious diseases in obstetrics and gynecology2012
Incidence of pregnancy after initiation of antiretroviral therapy in South Africa: a retrospective clinical cohort analysis.
Article in Infectious diseases in obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Representation of women and pregnant women in HIV research: a limited systematic review.PloS one · 2013Pooled it
- Determinants and Experiences of Repeat Pregnancy among HIV-Positive Kenyan Women--A Mixed-Methods Analysis.PloS one · 2015Trial
- Incident pregnancy and time to death or AIDS among HIV-positive women receiving antiretroviral therapy.PloS one · 2013Trial
- Pregnancy rates and outcomes in a longitudinal HIV cohort in the context of evolving antiretroviral treatment provision in South Africa.BMC pregnancy and childbirth · 2022Article
- Article
- Decreasing incidence of pregnancy among HIV-positive adolescents in a large HIV treatment program in western Kenya between 2005 and 2017: a retrospective cohort study.Reproductive health · 2020Article
- Pregnancy in women diagnosed with HIV on antiretroviral therapy in Ethiopia: a retrospective cohort study.The Pan African medical journal · 2020Article
- Patient-provider communication about pregnancy and HIV among female sex workers living with HIV in Santo Domingo, Dominican Republic.BMC pregnancy and childbirth · 2019Article
- Article
- Article
- Pregnancy incidence and intention after HIV diagnosis among women living with HIV in Canada.PloS one · 2017Article
- Pregnancy rate and birth outcomes among women receiving antiretroviral therapy in Burkina Faso: a retrospective cohort study.The Pan African medical journal · 2016Article
- Effect of pregnancy and the postpartum period on adherence to antiretroviral therapy among HIV-infected women established on treatment.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Incidence of pregnancy after antiretroviral therapy initiation and associated factors in 8 West African countries.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Injectable and oral contraception and the incidence and progression of cervical disease in HIV-infected women in South Africa.Contraception · 2014Observational
- Desire for fertility among HIV-seroconcordant and -discordant couples in Lusaka, Zambia.Culture, health & sexuality · 2014Article
- Reproductive and maternal healthcare needs of HIV infected women.Current HIV/AIDS reports · 2013Review
- Pregnancy incidence and associated factors among HIV-infected female adolescents in HIV care in urban Côte d'Ivoire, 2009-2013.Global health actionArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about rates of incident pregnancy among HIV-positive women initiating highly active antiretroviral therapy (HAART).
methodsWe conducted a retrospective clinical cohort study among therapy-naïve women ages 18-45 initiating HAART between 1 April 2004 and 30 September 2009 at an adult HAART clinic in Johannesburg, South Africa. We used Poisson regression to characterize rates and rate ratios of pregnancy.
resultsWe evaluated 5,996 women who experienced 727 pregnancies during 14,095 person-years at risk. The overall rate of pregnancy was 5.2 per 100 person-years (95% confidence limits [CL] 4.8, 5.5). By six years, cumulative incidence of first pregnancy was 22.9% (95% CL 20.6%, 25.4%); among women ages 18-25 at HAART initiation, cumulative incidence was 52.2% (95% CL 35.0%, 71.8%). The strongest predictor of incidence of pregnancy was age, with women 18-25 having 13.2 times the rate of pregnancy of women ages 40-45 in adjusted analysis. CD4 counts below 100 and worse adherence to HAART were associated with lower rates of incident pregnancy.
conclusionsWomen experience high rates of incident pregnancy after HAART initiation. Understanding which women are most likely to experience pregnancy will help planning and future efforts to understand the implications of pregnancy for response to HAART.
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