ArticleProceedings of the National Academy of Sciences of the United States of America2012
Chemotactic signaling via carbohydrate phosphotransferase systems in Escherichia coli.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Navigating bacterial motility through chemotaxis: from molecular mechanisms to physiological perspectives.Folia microbiologica · 2025Review
- Identification of Key Features Pivotal to the Characteristics and Functions of Gut Bacteria Taxa through Machine Learning Methods.Current gene therapy · 2025Article
- Structure and mechanism of a phosphotransferase system glucose transporter.Nature communications · 2024Article
- Ecological relevance of flagellar motility in soil bacterial communities.The ISME journal · 2024Article
- Identification of a dCache-type chemoreceptor inFrontiers in microbiology · 2024Article
- The implication of viability and pathogenicity by truncated lipopolysaccharide in Yersinia enterocolitica.Applied microbiology and biotechnology · 2023Article
- Physiological and Transcriptomic Analyses ofMicroorganisms · 2023Article
- Article
- Glucose Transport inMicroorganisms · 2023Review
- The Biological Significance of Pyruvate Sensing and Uptake inMicroorganisms · 2022Article
- Plant-Endophyte Interaction during Biotic Stress Management.Plants (Basel, Switzerland) · 2022Review
- Endophytism: A Multidimensional Approach to Plant-Prokaryotic Microbe Interaction.Frontiers in microbiology · 2022Review
- A traveling-wave solution for bacterial chemotaxis with growth.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Multiple functions of flagellar motility and chemotaxis in bacterial physiology.FEMS microbiology reviews · 2021Review
- Insights into a Pyruvate Sensing and Uptake System inJournal of bacteriology · 2021Article
- Article
- ThemSystems · 2021Article
- The Unconventional Cytoplasmic Sensing Mechanism for Ethanol Chemotaxis in Bacillus subtilis.mBio · 2020Article
- A Multi-Scale Approach to ModelingEntropy (Basel, Switzerland) · 2020Article
- Persister Cells Resuscitate Using Membrane Sensors that Activate Chemotaxis, Lower cAMP Levels, and Revive Ribosomes.iScience · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemotaxis allows bacteria to follow gradients of nutrients, environmental stimuli, and signaling molecules, optimizing bacterial growth and survival. Escherichia coli has long served as a model of bacterial chemotaxis, and the signal processing by the core of its chemotaxis pathway is well understood. However, most of the research so far has focused on one branch of chemotactic signaling, in which ligands bind to periplasmic sensory domains of transmembrane chemoreceptors and induce a conformational change that is transduced across the membrane to regulate activity of the receptor-associated kinase CheA. Here we quantitatively characterize another, receptor-independent branch of chemotactic signaling that is linked to the sugar uptake through a large family of phosphotransferase systems (PTSs). Using in vivo characterization of intracellular signaling and protein interactions, we demonstrate that signals from cytoplasmic PTS components are transmitted directly to the sensory complexes formed by chemoreceptors, CheA and an adapter protein CheW. We further conclude that despite different modes of sensing, the PTS- and receptor-mediated signals have similar regulatory effects on the conformation of the sensory complexes. As a consequence, both types of signals become integrated and undergo common downstream processing including methylation-dependent adaptation. We propose that such mode of signaling is essential for efficient chemotaxis to PTS substrates and may be common to most bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.