ArticleThe Journal of biological chemistry2012
Extracellular Ca(2+) sensing in salivary ductal cells.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Activation of CaExperimental brain research · 2025Article
- Reduction of TRPC1/TRPC3 mediated CaCellular signalling · 2023Article
- Ablation of TRPC3 disrupts CaScientific reports · 2023Article
- Anti-inflammatory role of extracellular l-arginine through calcium sensing receptor in human renal proximal tubular epithelial (HK-2) cells.International immunopharmacology · 2023Article
- Hypercalciuria switches CaGenes & diseases · 2022Article
- Alginate Hydrogel Microtubes for Salivary Gland Cell Organization and Cavitation.Bioengineering (Basel, Switzerland) · 2022Article
- Sci-Seq of Human Fetal Salivary Tissue Introduces Human Transcriptional Paradigms and a Novel Cell Population.Frontiers in dental medicine · 2022Article
- Differential biomolecular recognition by syntheticJournal of materials chemistry. B · 2021Article
- Modulation of Tubular pH by Acetazolamide in a CaInternational journal of molecular sciences · 2021Article
- Salivary proteomic profile of dogs with and without dental calculus.BMC veterinary research · 2020Article
- l-ornithine activates CaCellular signalling · 2020Article
- Physiological cAMP-elevating secretagogues differentially regulate fluid and protein secretions in mouse submandibular and sublingual glands.American journal of physiology. Cell physiology · 2019Article
- Evidence for a regulated CaJournal of cell science · 2019Article
- Systemic network for dietary inorganic phosphate adaptation among three organs.Pflugers Archiv : European journal of physiology · 2019Article
- Abrogation of store-operated CaCell death discovery · 2019Article
- Melamine induces CaAmerican journal of physiology. Cell physiology · 2017Article
- Calcium signalling in salivary gland physiology and dysfunction.The Journal of physiology · 2016Review
- Article
- Engineering of polarized tubular structures in a microfluidic device to study calcium phosphate stone formation.Lab on a chip · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Ca(2+) is secreted from the salivary acinar cells as an ionic constituent of primary saliva. Ions such as Na(+) and Cl(-) get reabsorbed whereas primary saliva flows through the salivary ductal system. Although earlier studies have shown that salivary [Ca(2+)] decreases as it flows down the ductal tree into the oral cavity, ductal reabsorption of Ca(2+) remains enigmatic. Here we report a potential role for the G protein-coupled receptor, calcium-sensing receptor (CSR), in the regulation of Ca(2+) reabsorption by salivary gland ducts. Our data show that CSR is present in the apical region of ductal cells where it is co-localized with transient receptor potential canonical 3 (TRPC3). CSR is activated in isolated salivary gland ducts as well as a ductal cell line (SMIE) by altering extracellular [Ca(2+)] or by aromatic amino acid, L-phenylalanine (L-Phe, endogenous component of saliva), as well as neomycin. CSR activation leads to Ca(2+) influx that, in polarized cells grown on a filter support, is initiated in the luminal region. We show that TRPC3 contributes to Ca(2+) entry triggered by CSR activation. Further, stimulation of CSR in SMIE cells enhances the CSR-TRPC3 association as well as surface expression of TRPC3. Together our findings suggest that CSR could serve as a Ca(2+) sensor in the luminal membrane of salivary gland ducts and regulate reabsorption of [Ca(2+)] from the saliva via TRPC3, thus contributing to maintenance of salivary [Ca(2+)]. CSR could therefore be a potentially important protective mechanism against formation of salivary gland stones (sialolithiasis) and infection (sialoadenitis).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.