ArticlePediatric pulmonology2013
A 4 year prospective study to determine risk factors for severe community acquired pneumonia in children in southern China.
Article in Pediatric pulmonology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02303587 (Low Dose Versus High Dose Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia), which is not on this map. Cited by 35 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low Dose Versus High Dose Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia : a Multicenter Randomized Blinded Trial
Who cites it
35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Hypoxaemia and mortality in children with lower respiratory infection in low-income and middle-income countries: systematic review and meta-analysis.The Lancet. Global health · 2026Pooled it
- Disease burden due to respiratory syncytial virus infection among under-5 children of India for 2020: a multiplicative model using meta-estimates.BMJ global health · 2025Pooled it
- Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- What are the risk factors for death among children with pneumonia in low- and middle-income countries? A systematic review.Journal of global health · 2023Pooled it
- Hospital utilization rates for influenza and RSV: a novel approach and critical assessment.Population health metrics · 2021Pooled it
- Breastfeeding and the Risk of Infant Illness in Asia: A Review.International journal of environmental research and public health · 2019Pooled it
- Pooled it
- Trial
- Construction and Validation of a Convenient Death Prediction Model for Pediatric Pneumonia Patients in Intensive Care Units.Indian journal of pediatrics · 2025Article
- Article
- Real-world efficacy and safety of cefepime for pediatric community-acquired pneumonia: a propensity score-matched study.Frontiers in cellular and infection microbiology · 2025Article
- Factors affecting survival of foals with pneumonia in a referral hospital.BMC veterinary research · 2024Article
- Recurrent Respiratory Infections in Children with Down Syndrome: A Review.Children (Basel, Switzerland) · 2024Review
- Review
- Etiological and clinical characteristics of severe pneumonia in pediatric intensive care unit (PICU).BMC pediatrics · 2023Article
- Vaccination in children with congenital heart disease: an observational study in a Beijing hospital.Pediatric research · 2023Observational
- Characteristics, management and changing incidence of children with empyema in a paediatric intensive care unit.Journal of paediatrics and child health · 2022Article
- Ventilator-associated pneumonia is linked to a worse prognosis than community-acquired pneumonia in children.PloS one · 2022Article
- A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland.Virologica Sinica · 2021Article
- Factors associated with mortality in pediatric pneumonia patients supported with mechanical ventilation in developing country.Heliyon · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPneumonia is the major cause of death under 5 years. With high CAP numbers in China and growing access to PICUs, factors associated with severe CAP need to be determined to optimize care.
objectiveTo prospectively determine PICU CAP admission features and outcomes.
methodsA 4 year prospective study of CAP aged 1 month to <14 years admitted to PICU, Children's Hospital Affiliated to Soochow University, China. All were managed in a standard manner. Clinical, laboratory, and imaging findings were collected systematically. All received antibiotics.
resultsEight hundred ten (7%) of 10,836 CAP hospital admissions needed PICU. Seven hundred seven (87%) were enrolled. PICU CAP children were young (76% ≤ 12 months) and 33% had co-morbid conditions; 21% congenital heart disease.21% required mechanical ventilation. The average length of PICU stay was 5 days (range, 3-27). The case fatality rate was 5.8%. Viruses were detected in 38%, RSV 24%; bacteria in 23%, Streptococcus pneumoniae 7%, Haemophilus influenza b 4%, Mycoplasma 11%. On single factor analysis, PICU admission respiratory rate >70/min, grunting/groaning, head nodding, cyanosis, and anemia were associated with respiratory failure and with fatality. On multivariate analysis only presence of congenital heart disease, Trisomy 21 and immunodeficiency correlated with fatality; not microbe nor PICU findings.
conclusionsYoung age and underlying congenital heart disease were associated factors for PICU support in CAP in China. Early referral if altered sensorium, high respiratory rate, head nodding, grunting and anemia, and universal access to conjugated vaccines may decrease morbidity and mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.