ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Won't You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity.Frontiers in cell and developmental biology · 2022Review
- Imaging Planar Cell Polarity Proteins in Xenopus Neuroectoderm.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Cryosectioning and Immunostaining ofCold Spring Harbor protocols · 2021Article
- Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation.Cell reports · 2021Article
- Rab7 is required for mesoderm patterning and gastrulation in Xenopus.Biology open · 2021Article
- Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation.Developmental cell · 2019Article
- Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo.Developmental biology · 2019Article
- Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate.eLife · 2018Article
- RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells.Journal of cell science · 2017Article
- Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth.Scientific reports · 2016Article
- Identifying domains of EFHC1 involved in ciliary localization, ciliogenesis, and the regulation of Wnt signaling.Developmental biology · 2016Article
- Emergence of an Apical Epithelial Cell Surface In Vivo.Developmental cell · 2016Article
- The involvement of PCP proteins in radial cell intercalations during Xenopus embryonic development.Developmental biology · 2015Article
- Centrin-2 (Cetn2) mediated regulation of FGF/FGFR gene expression in Xenopus.Scientific reports · 2015Article
- Neural crest specification by inhibition of the ROCK/Myosin II pathway.Stem cells (Dayton, Ohio) · 2015Article
- Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation.Development (Cambridge, England) · 2015Article
- Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression.Developmental biology · 2014Article
- Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1.The Journal of cell biology · 2014Article
- Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure.Nature communications · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundXenopus embryonic skin is composed of the superficial layer with defined apicobasal polarity and the inner layer lacking the apical domain. Multiciliated cells (MCCs) originate in the inner layer of the epidermal ectoderm and subsequently migrate to the surface. How MCCs acquire the apicobasal polarity and intercalate into the superficial layer during neurulation is largely unknown. As Rab11-dependent vesicle trafficking has been implicated in ciliary membrane assembly and in apical domain formation in epithelial cells, we assessed the involvement of Rab11 in MCC development.
resultsHere we report that Rab11 is specifically enriched and becomes apically polarized in skin MCCs. Interference with Rab11 function by overexpression of a dominant negative mutant or injection of a specific morpholino oligonucleotide inhibited MCC intercalation into the superficial layer. Dominant negative Rab11-expressing MCC precursors revealed intrinsic apicobasal polarity, characterized by the apical domain, which is not normally observed in inner layer cells. Despite the presence of the apical domain, the cells with inhibited Rab11 function were randomly oriented relative to the plane of the tissue, thereby demonstrating a defect in planar polarity.
conclusionsThese results establish a requirement for Rab11 in MCC development and support a two-step model, in which the initial polarization of MCC precursors is critical for their integration into the superficial cell layer.
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