ArticleThe Journal of comparative neurology2012
Organizational motifs for ground squirrel cone bipolar cells.
Article in The Journal of comparative neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.Nature communications · 2023Article
- Characterization of Retinal Development in 13-Lined Ground Squirrels.Translational vision science & technology · 2022Article
- Digital reconstruction and quantitative morphometric analysis of bipolar cells in live rat retinal slices.The Journal of comparative neurology · 2022Article
- Article
- Ground squirrel - A cool model for a bright vision.Seminars in cell & developmental biology · 2020Review
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
- Article
- Developmental and adult characterization of secretagogin expressing amacrine cells in zebrafish retina.PloS one · 2017Article
- Seasonal and post-trauma remodeling in cone-dominant ground squirrel retina.Experimental eye research · 2016Review
- Article
- Ocular Stem Cell Research from Basic Science to Clinical Application: A Report from Zhongshan Ophthalmic Center Ocular Stem Cell Symposium.International journal of molecular sciences · 2016Article
- Noninvasive imaging of the thirteen-lined ground squirrel photoreceptor mosaic.Visual neuroscience · 2016Article
- Fixation strategies for retinal immunohistochemistry.Progress in retinal and eye research · 2015Review
- Receptive field properties of bipolar cell axon terminals in direction-selective sublaminas of the mouse retina.Journal of neurophysiology · 2014Article
- Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Kainate receptor subunit diversity underlying response diversity in retinal off bipolar cells.The Journal of physiology · 2014Article
- Short-wavelength cone-opponent retinal ganglion cells in mammals.Visual neuroscience · 2014Review
- Three distinct blue-green color pathways in a mammalian retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing Cre transgenic mouse lines.Molecular vision · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
In daylight vision, parallel processing starts at the cone synapse. Cone signals flow to On and Off bipolar cells, which are further divided into types according to morphology, immunocytochemistry, and function. The axons of the bipolar cell types stratify at different levels in the inner plexiform layer (IPL) and can interact with costratifying amacrine and ganglion cells. These interactions endow the ganglion cell types with unique functional properties. The wiring that underlies the interactions among bipolar, amacrine, and ganglion cells is poorly understood. It may be easier to elucidate this wiring if organizational rules can be established. We identify 13 types of cone bipolar cells in the ground squirrel, 11 of which contact contiguous cones, with the possible exception of short-wavelength-sensitive cones. Cells were identified by antibody labeling, tracer filling, and Golgi-like filling following transduction with an adeno-associated virus encoding for green fluorescent protein. The 11 bipolar cell types displayed two organizational patterns. In the first pattern, eight to 10 of the 11 types came in pairs with partially overlapping axonal stratification. Pairs shared morphological, immunocytochemical, and functional properties. The existence of similar pairs is a new motif that might have implications for how signals first diverge from a cone to bipolar cells and then reconverge onto a costratifying ganglion cell. The second pattern is a mirror symmetric organization about the middle of the IPL involving at least seven bipolar cell types. This anatomical symmetry may be associated with a functional symmetry in On and Off ganglion cell responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.