Evidence map›Paper›PMID 22777977›Full record

ArticleThe Hastings Center report

Prenatal whole genome sequencing: just because we can, should we?

Greer Donley, Sara Chandros Hull, Benjamin E Berkman

Registry-linked trialAbstract read
In one paragraph

Article in The Hastings Center report. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03482141 (Clinical Utility of Prenatal Whole Exome Sequencing), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03482141 nacompletednot on this map

Clinical Utility of Prenatal Whole Exome Sequencing

TypeinterventionalSponsorUniversity of California, San FranciscoRan2017 to 2022Enrolled316ConditionsStructural Anomalies, Cardiac Anomalies, Central Nervous System Anomalies, Thorax AnomaliesArmsWhole Exome Sequencing (WES)
3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. What Really Matters Now in Prenatal Genetics.The American journal of bioethics : AJOB · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Next-generation sequencing and prenatal 'omics: advanced diagnostics and new insights into human development.Genetics in medicine : official journal of the American College of Medical Genetics · 2018
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Consenting for molecular diagnostics.Clinical chemistry · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Greer Donley
Sara Chandros Hull
Benjamin E Berkman

Funding

NHGRI/DIR Bioethics CoreZIDHG200347 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BERKMAN, BENJAMIN · 2010 to 2025
$15.5M
Intramural NIH HHS Z99 HG999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Health PolicyFemaleGenetic CounselingGenetic TestingGenome, HumanHumansPractice Guidelines as TopicPregnancyPrenatal DiagnosisSequence Analysis, DNAUnited States

Identifiers

PMID22777977
PMCPMC4113095

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.