ArticleHypertension (Dallas, Tex. : 1979)2012
Elderly blacks have a blunted sympathetic neural responsiveness but greater pressor response to orthostasis than elderly whites.
Article in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Integrative Blood Pressure Response to Upright Tilt Post Renal Denervation.American journal of hypertension · 2017Trial
- Insulin resistance is potentially associated with 24-h blood pressure variability related to blunted sympathetic reactivity in older adults with hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Greater resting muscle sympathetic nerve activity reduces cold pressor autonomic reactivity in older women, but not older men.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS-CoV-2 infection.Physiological reports · 2022Article
- Differential influences of dietary sodium on blood pressure regulation based on race and sex.Autonomic neuroscience : basic & clinical · 2021Review
- Keeping hope alive: Racial-ethnic disparities in distress tolerance are mitigated by religious/spiritual hope among Black Americans.Journal of psychosomatic research · 2021Article
- Sympathetic transduction in humans: recent advances and methodological considerations.American journal of physiology. Heart and circulatory physiology · 2021Review
- Clinical and neurohormonal characteristics in African Americans with neurogenic orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Race and sex differences in cardiovascular autonomic regulation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Racial disparities in cardiovascular disease risk: mechanisms of vascular dysfunction.American journal of physiology. Heart and circulatory physiology · 2019Review
- Sympathetic neural reactivity to mental stress differs in black and non-Hispanic white adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- The association between alcohol abuse and neuroendocrine system dysregulation: Race differences in a National sample.Brain, behavior, and immunity · 2017Article
- Sympathetic Neural and Hemodynamic Responses During Cold Pressor Test in Elderly Blacks and Whites.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Neural-humoral responses during head-up tilt in healthy young white and black women.Frontiers in physiology · 2014Article
- Response to creatine kinase and pressor response to orthostatic tolerance.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Microneurographic research in women.Frontiers in physiology · 2012Article
- Racial and ethnic disparities in cardiometabolic disease and COVID-19 outcomes in White, Black/African American, and Latinx populations: Physiological underpinnings.Progress in cardiovascular diseasesReview
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Abstract
Neural control of blood pressure (BP) has been reported to differ between young blacks and whites. We hypothesized that elderly blacks have enhanced sympathetic neural responses during orthostasis compared with elderly whites. Muscle sympathetic nerve activity, arm-cuff BP, and heart rate were recorded continuously, and cardiac output, stroke volume, and total peripheral resistance were measured intermittently during supine and 5-minute 60° upright tilt in 10 blacks (65 [SD, 4] years; 4 women) and 20 whites (68 [6] years; 8 women). We found that muscle sympathetic nerve activity burst frequency was similar between blacks and whites in the supine position (44 [10] versus 42 [7] bursts per minute) and during upright tilt (59 [11] versus 60 [9] bursts per minute; P=0.846 for race, P<0.001 for posture, and P=0.622 for interaction). However, upright total muscle sympathetic nerve activity was smaller in blacks than in whites (162 [39] versus 243 [112]%; P=0.003). Systolic BP, heart rate, cardiac output, and stroke volume were not different between groups. Diastolic BP was similar in the supine position, increased in all of the subjects during tilting; upright diastolic BP was greater in blacks than in whites (80 [10] versus 71 [7] mmHg; P=0.008). Total peripheral resistance did not differ between blacks and whites in the supine position or during upright tilt (P=0.354 for race, P<0.001 for posture, P=0.825 for interaction). Thus, elderly blacks have a blunted sympathetic neural responsiveness but enhanced pressor response to orthostasis compared with elderly whites, which may be attributable to an augmented sympathetic vascular transduction and/or nonadrenergic vasoconstrictor mechanisms (ie, angiotensin II or the venoarteriolar response).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.