ArticleProteins2012
The catalytic domain of the germination-specific lytic transglycosylase SleB from Bacillus anthracis displays a unique active site topology.
Article in Proteins, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- YpeB stability affects germination possibly through delaying SleB activity inJournal of bacteriology · 2026Article
- Structural and functional analysis ofMicrobiology (Reading, England) · 2025Article
- Structure of MltG from Mycobacterium abscessus reveals structural plasticity between composed domains.IUCrJ · 2024Article
- Identification of type VI secretion system effector-immunity pairs using structural bioinformatics.Molecular systems biology · 2024Article
- Horizontally acquired antibacterial genes associated with adaptive radiation of ladybird beetles.BMC biology · 2021Article
- YpeB dimerization may be required to stabilize SleB for effective germination of Bacillus anthracis spores.BMC microbiology · 2019Article
- Lytic transglycosylases: concinnity in concision of the bacterial cell wall.Critical reviews in biochemistry and molecular biology · 2017Review
- Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation.The Journal of biological chemistry · 2016Article
- Identification of MltG as a potential terminase for peptidoglycan polymerization in bacteria.Molecular microbiology · 2016Article
- Role of YpeB in cortex hydrolysis during germination of Bacillus anthracis spores.Journal of bacteriology · 2014Article
- Germination of spores of Bacillus species: what we know and do not know.Journal of bacteriology · 2014Review
- Spore germination mediated by Bacillus megaterium QM B1551 SleL and YpeB.Journal of bacteriology · 2014Article
- Functional analysis of SleC from Clostridium difficile: an essential lytic transglycosylase involved in spore germination.Microbiology (Reading, England) · 2014Article
- Activity and regulation of various forms of CwlJ, SleB, and YpeB proteins in degrading cortex peptidoglycan of spores of Bacillus species in vitro and during spore germination.Journal of bacteriology · 2013Article
- Bacterial cell-wall recycling.Annals of the New York Academy of Sciences · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Bacillus anthracis produces metabolically inactive spores. Germination of these spores requires germination-specific lytic enzymes (GSLEs) that degrade the unique cortex peptidoglycan to permit resumption of metabolic activity and outgrowth. We report the first crystal structure of the catalytic domain of a GSLE, SleB. The structure revealed a transglycosylase fold with unique active site topology and permitted identification of the catalytic glutamate residue. Moreover, the structure provided insights into the molecular basis for the specificity of the enzyme for muramic-δ-lactam-containing cortex peptidoglycan. The protein also contains a metal-binding site that is positioned directly at the entrance of the substrate-binding cleft.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.