ArticleMolecular reproduction and development2012
The forkhead transcription factor FoxY regulates Nanos.
Article in Molecular reproduction and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Collagen processing is essential for germ cell identity.Biology open · 2025Article
- Micromere formation and its evolutionary implications in the sea urchin.Current topics in developmental biology · 2022Article
- A single cell RNA sequencing resource for early sea urchin development.Development (Cambridge, England) · 2020Article
- Distinct transcriptional regulation of Nanos2 in the germ line and soma by the Wnt and delta/notch pathways.Developmental biology · 2019Article
- Trapping, tagging and tracking: Tools for the study of proteins during early development of the sea urchin.Methods in cell biology · 2019Review
- Article
- Germ Line Versus Soma in the Transition from Egg to Embryo.Current topics in developmental biology · 2015Review
- The biology of the germ line in echinoderms.Molecular reproduction and development · 2014Review
- Every which way--nanos gene regulation in echinoderms.Genesis (New York, N.Y. : 2000) · 2014Review
- Myogenesis in the sea urchin embryo: the molecular fingerprint of the myoblast precursors.EvoDevo · 2013Article
- Notch and Nodal control forkhead factor expression in the specification of multipotent progenitors in sea urchin.Development (Cambridge, England) · 2013Article
- The small GTPase Arf6 regulates sea urchin morphogenesis.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
FoxY is a member of the forkhead transcription factor family that appeared enriched in the presumptive germ line of sea urchins (Ransick et al. Dev Biol 2002;246:132). Here, we test the hypothesis that FoxY is involved in germ line determination in this animal. We found two splice forms of FoxY that share the same DNA-binding domain, but vary in the carboxy-terminal trans-activation/repression domain. Both forms of the FoxY protein are present in the egg and in the early embryo, and their mRNAs accumulate to their highest levels in the small micromeres and adjacent non-skeletogenic mesoderm. Knockdown of FoxY resulted in a dramatic decrease in Nanos mRNA and protein levels as well as a loss of coelomic pouches in 2-week-old larvae. Our results indicate that FoxY positively regulates Nanos at the transcriptional level and is essential for reproductive potential in this organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.