ArticleThe Journal of physiology2012
Preinspiratory calcium rise in putative pre-Botzinger complex astrocytes.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Glutamate tone in preBötzinger complex rhythmogenesis: ambient extracellular glutamate as a candidate excitability bias.Pflugers Archiv : European journal of physiology · 2026Review
- Review
- Astrocytic Connexin43 Channels Are Essential for Breathing Pattern Stabilization in the preBötzinger Complex.CNS neuroscience & therapeutics · 2025Article
- Persistence of post-stress blood pressure elevation requires activation of astrocytes.Scientific reports · 2024Article
- Review
- Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex.The Journal of physiology · 2024Article
- Shining the Light on Astrocytic Ensembles.Cells · 2023Review
- Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling.Frontiers in cellular neuroscience · 2023Article
- The endocannabinoid system and breathing.Frontiers in neuroscience · 2023Review
- Fiber optical imaging of astroglial calcium signaling in the respiratory network in the working heart brainstem preparation.Frontiers in physiology · 2023Article
- Minocycline prevents hypoxia-induced seizures.Frontiers in neural circuits · 2023Article
- Glycine and GABAA receptors suppressively regulate the inspiratory-related calcium rise in the thoracic inspiratory cells of the neonatal rat.The journal of physiological sciences : JPS · 2022Article
- Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences.The journal of physiological sciences : JPS · 2022Review
- Novel oxygen sensing mechanism in the spinal cord involved in cardiorespiratory responses to hypoxia.Science advances · 2022Article
- Astrocytes and Behavior.Annual review of neuroscience · 2021Article
- Review
- Activation of Astrocytes in the Persistence of Post-hypoxic Respiratory Augmentation.Frontiers in physiology · 2021Article
- Calcium Imaging Analysis of Cellular Responses to Hypercapnia and Hypoxia in the NTS of Newborn Rat Brainstem Preparation.Frontiers in physiology · 2021Article
- Bi-Directional Communication Between Neurons and Astrocytes Modulates Spinal Motor Circuits.Frontiers in cellular neuroscience · 2020Article
- Characterisation of medullary astrocytic populations in respiratory nuclei and alterations in sudden unexpected death in epilepsy.Epilepsy research · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural inspiratory activity originates from a ventrolateral medullary region called the pre-Bötzinger complex (preBötC), yet the mechanism underlying respiratory rhythmogenesis is not completely understood. Recently, the role of not only neurons but astrocytes in the central respiratory control has attracted considerable attention. Here we report our discovery that an intracellular calcium rise in a subset of putative astrocytes precedes inspiratory neuronal firing in rhythmically active slices. Functional calcium imaging from hundreds of preBötC cells revealed that a subset of putative astrocytes exhibited rhythmic calcium elevations preceding inspiratory neuronal activity with a time lag of approximately 2 s. These preinspiratory putative astrocytes maintained their rhythmic activities even during the blockade of neuronal activity with tetrodotoxin, whereas the rhythm frequency was lowered and the intercellular phases of these rhythms were decoupled. In addition, optogenetic stimulation of preBötC putative astrocytes induced firing of inspiratory neurons. These findings raise the possibility that astrocytes in the preBötC are actively involved in respiratory rhythm generation in rhythmically active slices.
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