ReviewSeminars in immunopathology2012
Early life precursors, epigenetics, and the development of food allergy.
Review in Seminars in immunopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.Nature communications · 2015Pooled it
- Age-, Sex- and Region-Specific Patterns in Sensitization Rates to Food Allergens and Food Allergy Prevalence in Croatian Children: The H2020 IMPTOX and ERDF P4 Study Findings.Children (Basel, Switzerland) · 2026Article
- Regulatory T cells and their role in allergic disease.Allergy · 2025Review
- The methylation profile ofFrontiers in immunology · 2023Article
- Trained innate immunity, epigenetics, and food allergy.Frontiers in allergy · 2023Review
- Article
- Nutrition during Pregnancy and Lactation: Epigenetic Effects on Infants' Immune System in Food Allergy.Nutrients · 2022Review
- Epigenetics in Food Allergy and Immunomodulation.Nutrients · 2021Review
- Raw Milk-Induced Protection against Food Allergic Symptoms in Mice Is Accompanied by Shifts in Microbial Community Structure.International journal of molecular sciences · 2021Article
- Targeted DNA methylation profiling reveals epigenetic signatures in peanut allergy.JCI insight · 2021Article
- Developmental origin and sex-specific risk for infections and immune diseases later in life.Seminars in immunopathology · 2019Review
- Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor.Frontiers in genetics · 2019Article
- A curated collection of transcriptome datasets to investigate the molecular mechanisms of immunoglobulin E-mediated atopic diseases.Database : the journal of biological databases and curation · 2019Article
- Solid Food Introduction and the Development of Food Allergies.Nutrients · 2018Review
- Forkhead box protein 3 demethylation is associated with tolerance induction in peanut-induced intestinal allergy.The Journal of allergy and clinical immunology · 2018Article
- Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait.International journal of pediatrics · 2018Article
- Epigenetic Changes During Food-Specific Immunotherapy.Current allergy and asthma reports · 2016Review
- Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry.The Journal of allergy and clinical immunology · 2016Review
- Regulatory T cells in allergic diseases.The Journal of allergy and clinical immunology · 2016Review
- Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy.The Journal of allergy and clinical immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Food allergy (FA), a major clinical and public health concern worldwide, is caused by a complex interplay of environmental exposures, genetic variants, gene-environment interactions, and epigenetic alterations. This review summarizes recent advances surrounding these key factors, with a particular focus on the potential role of epigenetics in the development of FA. Epidemiologic studies have reported a number of nongenetic factors that may influence the risk of FA, such as timing of food introduction and feeding pattern, diet/nutrition, exposure to environmental tobacco smoking, prematurity and low birth weight, microbial exposure, and race/ethnicity. Current studies on the genetics of FA are mainly conducted using candidate gene approaches, which have linked more than 10 genes to the genetic susceptibility of FA. Studies on gene-environment interactions of FA are very limited. Epigenetic alteration has been proposed as one of the mechanisms to mediate the influence of early life environmental exposures and gene-environment interactions on the development of diseases later in life. The role of epigenetics in the regulation of the immune system and the epigenetic effects of some FA-associated environmental exposures are discussed in this review. There is a particular lack of large-scale prospective birth cohort studies that simultaneously assess the interrelationships of early life exposures, genetic susceptibility, epigenomic alterations, and the development of FA. The identification of these key factors and their independent and joint contributions to FA will allow us to gain important insight into the biological mechanisms by which environmental exposures and genetic susceptibility affect the risk of FA and will provide essential information to develop more effective new paradigms in the diagnosis, prevention, and management of FA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.