Trial reportCerebellum (London, England)2013
Role of cerebellum in motion perception and vestibulo-ocular reflex-similarities and disparities.
Trial report in Cerebellum (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Skull vibration induced nystagmus, velocity storage and self-stability.Frontiers in neurology · 2025Article
- Article
- Exploring Heading Direction Perception in Cervical Dystonia, Tremor, and Their Coexistence.Brain sciences · 2024Article
- Differences in the Distribution of Aβ in the Brain between U.S. Veterans and Adults aged 62+ and suffering from Alzheimer's Disease.Annals of biostatistics & biometric applications · 2024Article
- Spatial memory and learning: investigating the role of dynamic visual acuity.Frontiers in behavioral neuroscience · 2024Article
- Cognition in vestibular disorders: state of the field, challenges, and priorities for the future.Frontiers in neurology · 2024Review
- Learning capabilities to resolve tilt-translation ambiguity in goldfish.Frontiers in neurology · 2024Article
- Correlates for Human Self-Rotation Estimators Are Found.Cerebellum (London, England) · 2023Article
- In Vivo Localization of the Human Velocity Storage Mechanism and Its Core Cerebellar Networks by Means of Galvanic-Vestibular Afternystagmus and fMRI.Cerebellum (London, England) · 2023Article
- Visual Perception of Heading in the Syndrome of Oculopalatal Tremor.Cerebellum (London, England) · 2021Article
- Does Inferior-Olive Hypersynchrony Affect Vestibular Heading Perception?Cerebellum (London, England) · 2021Article
- Lessons learned from the syndrome of oculopalatal tremor.Journal of computational neuroscience · 2021Review
- Severity-Dependent Effects of Parkinson's Disease on Perception of Visual and Vestibular Heading.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- COMPASS: Computations for Orientation and Motion Perception in Altered Sensorimotor States.Frontiers in neural circuits · 2021Article
- Development of a conversion model between mechanical and electrical vestibular stimuli.Journal of neurophysiology · 2020Article
- Vertigo in Cerebellar Disease-Do the Eyes Have It or Is There More to Perceive?Cerebellum (London, England) · 2019Article
- Assessing misperception of rotation in benign paroxysmal positional vertigo with static and dynamic visual images.Journal of vestibular research : equilibrium & orientation · 2019Article
- Vestibular and Multi-Sensory Influences Upon Self-Motion Perception and the Consequences for Human Behavior.Frontiers in neurology · 2019Review
- Eye Movement Research in the Twenty-First Century-a Window to the Brain, Mind, and More.Cerebellum (London, England) · 2018Article
- Effects of Deep Brain Stimulation on Eye Movements and Vestibular Function.Frontiers in neurology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Vestibular velocity storage enhances the efficacy of the angular vestibulo-ocular reflex (VOR) during relatively low-frequency head rotations. This function is modulated by GABA-mediated inhibitory cerebellar projections. Velocity storage also exists in perceptual pathway and has similar functional principles as VOR. However, it is not known whether the neural substrate for perception and VOR overlap. We propose two possibilities. First, there is the same velocity storage for both VOR and perception; second, there are nonoverlapping neural networks: one might be involved in perception and the other for the VOR. We investigated these possibilities by measuring VOR and perceptual responses in healthy human subjects during whole-body, constant-velocity rotation steps about all three dimensions (yaw, pitch, and roll) before and after 10 mg of 4-aminopyridine (4-AP). 4-AP, a selective blocker of inward rectifier potassium conductance, can lead to increased synchronization and precision of Purkinje neuron discharge and possibly enhance the GABAergic action. Hence 4-AP could reduce the decay time constant of the perceived angular velocity and VOR. We found that 4-AP reduced the decay time constant, but the amount of reduction in the two processes, perception and VOR, was not the same, suggesting the possibility of nonoverlapping or partially overlapping neural substrates for VOR and perception. We also noted that, unlike the VOR, the perceived angular velocity gradually built up and plateau prior to decay. Hence, the perception pathway may have additional mechanism that changes the dynamics of perceived angular velocity beyond the velocity storage. 4-AP had no effects on the duration of build-up of perceived angular velocity, suggesting that the higher order processing of perception, beyond the velocity storage, might not occur under the influence of mechanism that could be influenced by 4-AP.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.