Evidence map›Paper›PMID 22777399›Full record

ArticleCurrent allergy and asthma reports2012

Strategies for molecular classification of asthma using bipartite network analysis of cytokine expression.

Regina R Pillai, Rohit Divekar, Allan Brasier, Suresh Bhavnani, William J Calhoun

Abstract read
In one paragraph

Article in Current allergy and asthma reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Relationship between asthma status and antibody response pattern to 23-valent pneumococcal vaccination.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Identifying phenotypic signatures of neuropsychiatric disorders from electronic medical records.Journal of the American Medical Informatics Association : JAMIA · 2013
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Regina R PillaiDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Medical Branch, 5.140 John Sealy Annex, 301 University Blvd, Galveston, TX 77555-0561, USA. rrpillai@utmb.edu
Rohit Divekar
Allan Brasier
Suresh Bhavnani
William J Calhoun

Funding

WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
NCATS NIH HHS UL1 TR000071NCRR NIH HHS M01 RR000056
6 · The paper itself

Abstract

Asthma is a chronic inflammatory disease of the airways that leads to various degrees of recurrent respiratory symptoms affecting patients globally. Specific subgroups of asthma patients have severe disease leading to increased healthcare costs and socioeconomic burden. Despite the overwhelming prevalence of the asthma, there are limitations in predicting response to therapy and identifying patients who are at increased risk of morbidity. This syndrome presents with common clinical signs and symptoms; however, awareness of subgroups of asthma patients with distinct characteristics has surfaced in recent years. Investigators attempt to describe the phenotypes of asthma to ultimately assist with diagnostic and therapeutic applications. Approaches to asthma phenotyping are multifold; however, it can be partitioned into 2 essential groups, clinical phenotyping and molecular phenotyping. Innovative techniques such as bipartite network analysis and visual analytics introduce a new dimension of data analysis to identify underlying mechanistic pathways.

Indexed as

Neural Networks, ComputerArtificial IntelligenceAsthmaAsthma, Exercise-InducedCluster AnalysisCytokinesGene Expression RegulationHumansLogistic ModelsModels, BiologicalPhenotypeRespiratory HypersensitivitySystems BiologyCytokines

Identifiers

PMID22777399
PMCPMC3573881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.