ReviewHistochemistry and cell biology2012
"Tasting" the airway lining fluid.
Review in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Lung development and regeneration: newly defined cell types and progenitor status.Cell regeneration (London, England) · 2023Review
- In situ structure of intestinal apical surface reveals nanobristles on microvilli.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Isolation of Nasal Brush Cells for Single-cell Preparations.Bio-protocol · 2021Article
- Morphology of GNAT3-immunoreactive chemosensory cells in the nasal cavity and pharynx of the rat.Journal of anatomy · 2021Article
- Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice.Cell and tissue research · 2021Article
- Unique nasal septal island in dromedary camels may play a role in pain perception: microscopic studies.Saudi journal of biological sciences · 2021Article
- Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2.Science immunology · 2020Article
- Actin Dynamics Drive Microvillar Motility and Clustering during Brush Border Assembly.Developmental cell · 2019Article
- Cellular crosstalk in the development and regeneration of the respiratory system.Nature reviews. Molecular cell biology · 2019Review
- The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Morphology of GNAT3-immunoreactive chemosensory cells in the rat larynx.Journal of anatomy · 2019Article
- Building and Regenerating the Lung Cell by Cell.Physiological reviews · 2019Review
- Preterm Birth Affects the Risk of Developing Immune-Mediated Diseases.Frontiers in immunology · 2017Article
- Article
- Chemosensory epithelial cells in the urethra: sentinels of the urinary tract.Histochemistry and cell biology · 2016Review
- From modeling to remodeling of upper airways: Centrality of hyaluronan (hyaluronic acid).International journal of immunopathology and pharmacology · 2016Article
- PeakForce Tapping resolves individual microvilli on living cells.Journal of molecular recognition : JMR · 2016Article
- Morphology of P2X3-immunoreactive nerve endings in the rat laryngeal mucosa.Histochemistry and cell biology · 2016Article
- Cholinergic epithelial cell with chemosensory traits in murine thymic medulla.Cell and tissue research · 2014Article
- Non-neuronal cholinergic system in airways and lung cancer susceptibility.Translational lung cancer research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specialized epithelial cells of the respiratory tract have been termed "solitary chemosensory cells" based upon the expression of components of the canonical sweet, umami and bitter taste transduction pathway, or "brush cells" based upon their characteristic morphological feature, i.e. an apical, brush-like tuft of rigid, villin containing microvilli. Cells defined by these criteria might not match one-to-one, and a generally accepted terminology is still lacking. With respect to cellular shape, ultrastructure, expression of elements of the taste transduction cascade, innervation and synapse formation, and effects evoked upon their stimulation, it appears that chemosensory/brush in the upper respiratory tract (nasal respiratory mucosa, vomeronasal duct, auditory tube), in the olfactory mucosa, in the larynx, in the lower airways (trachea, bronchi) and in the alveolar region (rat only) each represent distinct groups. Still, they have in common to monitor the chemical composition of the mucosal lining fluid. They serve as sentinels detecting bacterial colonization or the presence of other harmful components in the mucosal lining fluid, leading to the initiation of avoidance reflexes and/or local defense mechanisms which are adapted to their anatomical localization. Free nerve endings are also responsive to inhaled irritants and further work will be needed to discriminate between the contributions of such nerve endings and chemosensory cells in chemical monitoring and defense initiation. Interestingly, there is first emerging evidence that respiratory chemosensory cells may respond to more than one canonical taste quality so that they, in analogy to polymodal nociceptors, may serve as polymodal chemosensors of potentially dangerous signals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.