ArticleHistochemistry and cell biology2012
Fibroblast growth factor receptor 3 is highly expressed in rarely dividing human type A spermatogonia.
Article in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- DMRT1 haploinsufficiency leads to secondary infertility in XY male rabbits†.Biology of reproduction · 2025Article
- Systematic screening and dynamic profiling of germline regulatory pathways and spermatogonial surface markers in a bivalve mollusc.Computational and structural biotechnology journal · 2025Article
- Microenvironment of spermatogonial stem cells: a key factor in the regulation of spermatogenesis.Stem cell research & therapy · 2024Review
- Conserved Transcriptome Features Define Prepubertal Primate Spermatogonial Stem Cells as AInternational journal of molecular sciences · 2023Article
- Article
- Application of single-cell RNA sequencing on human testicular samples: a comprehensive review.International journal of biological sciences · 2023Review
- FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes.Stem cell reports · 2022Article
- Primary culture of germ cells that portray stem cell characteristics and recipient preparation for autologous transplantation in the rhesus monkey.Journal of cellular and molecular medicine · 2022Article
- Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis.Journal of animal science and biotechnology · 2021Article
- Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis.Cell reports. Medicine · 2021Article
- CellCall: integrating paired ligand-receptor and transcription factor activities for cell-cell communication.Nucleic acids research · 2021Article
- An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer.Stem cell reviews and reports · 2021Review
- The Progresses of Spermatogonial Stem Cells Sorting Using Fluorescence-Activated Cell Sorting.Stem cell reviews and reports · 2020Review
- Spermatogonial stem cells and spermatogenesis in mice, monkeys and men.Stem cell research · 2018Review
- Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers.Annual review of genomics and human genetics · 2016Review
- Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Fibroblast Growth Factor Receptors (FGFRs) in Human Sperm: Expression, Functionality and Involvement in Motility Regulation.PloS one · 2015Article
- Characterization of human spermatogonial stem cell markers in fetal, pediatric, and adult testicular tissues.Reproduction (Cambridge, England) · 2014Article
- Testicular niche required for human spermatogonial stem cell expansion.Stem cells translational medicine · 2014Article
- Fluorescence- and magnetic-activated cell sorting strategies to isolate and enrich human spermatogonial stem cells.Fertility and sterility · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human spermatogonia (Spg) and their fetal precursors express fibroblast growth factor receptor 3 (FGFR3). To further elucidate the role of FGFR3 in the control of Spg self-renewal, proliferation, and/or differentiation, and to narrow down the FGFR3-positive cell type(s) in the normal adult human testis, tissue sections and whole mount preparations of seminiferous tubules were analyzed combining immunofluorescence and confocal fluorescence microscopy. FGFR3 protein was chiefly observed in cellular membranes and cytoplasmic vesicles of a subpopulation of type A Spg, which comprised the chromatin rarefaction zone-containing type A(dark). Cytoplasmic expression of FGFR3 and nuclear expression of proliferation-associated antigen KI-67 were mutually exclusive. Similarly, FGFR3-positive Spg were negative for Doublesex and Mab-3 related transcription factor 1 (DMRT1). By contrast, undifferentiated embryonic cell transcription factor 1 (UTF1) and survival time-associated PHD finger in ovarian cancer 1 protein (SPOC1) were co-expressed in the nuclei of FGFR3-positive Spg. Whole mounted seminiferous tubules illustrated the clonogenic arrangement of the FGFR3/UTF1 double-positive Spg, which mainly occurred as pairs or quadruplets and, different from the KIT-positive Spg, showed no overlap with KI-67 labeled clusters. Taken together, in the adult human testis, FGFR3 expression is a feature of small clones of rarely dividing type A Spg which resemble "undifferentiated" Spg, including the spermatogonial stem cells.
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