Evidence map›Paper›PMID 22777209›Full record

ArticleMolecular biology reports2012

Effect of polysaccharides extract of rhizoma atractylodis macrocephalae on thymus, spleen and cardiac indexes, caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein and mRNA expression levels in aged rats.

Ling Guo, Yong Le Sun, Ai Hong Wang, Chong En Xu, Meng Yuan Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Meta-Analysis on the Chinese Herbal FormulaFrontiers in pharmacology · 2020
    Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Polysaccharides fromEvidence-based complementary and alternative medicine : eCAM · 2022
    Review
  8. Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020
    Article
  9. Polysaccharide ofFrontiers in pharmacology · 2020
    Article
  10. Immunomodulatory Effects of theMolecules (Basel, Switzerland) · 2019
    Article
  11. The polysaccharide ofRSC advances · 2018
    Article
  12. Effect of ModifiedEvidence-based complementary and alternative medicine : eCAM · 2017
    Article
  13. Article
  14. Impact of X-linked inhibitor of apoptosis protein on survival of nasopharyngeal carcinoma patients following radiotherapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ling GuoDepartment of Cardiology, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan 250021, Shandong, People's Republic of China.
Yong Le Sun
Ai Hong Wang
Chong En Xu
Meng Yuan Zhang
Shandong University · CNShandong Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to determine the possible protective effect of polysaccharides extract of rhizoma atractylodis macrocephalae on heart function in aged rats. Polysaccharides extract of rhizoma atractylodis macrocephalae was administered to aged rats. Results showed that thymus, spleen and cardiac indexs were significantly increased, whereas caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein expression, Smac/DIABLO and HtrA2/Omi mRNA expression levels were markedly reduced. It can be concluded that polysaccharides extract of rhizoma atractylodis macrocephalae may enhance immunity and improve heart function in aged rats.

Indexed as

AnimalsApoptosis Regulatory ProteinsAtractylodesCardiotonic AgentsCarrier ProteinsCaspase 3FemaleGene ExpressionHeartHemodynamicsImmunologic FactorsMaleMitochondrial ProteinsNerve Tissue ProteinsPlant ExtractsPolysaccharidesApoptosis Regulatory ProteinsCardiotonic AgentsCarrier ProteinsCasp3 protein, ratCaspase 3DIABLO protein, ratImmunologic FactorsMitochondrial ProteinsNerve Tissue ProteinsPlant ExtractsPolysaccharidesRNA-Binding ProteinsRNA, MessengerSerine-Arginine Splicing FactorsTra2b protein, rat

Identifiers

PMID22777209
OpenAlexW2035475301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.