Evidence map›Paper›PMID 22777128›Full record

ReviewNature reviews. Genetics2012

The place of genetics in ageing research.

Nir Barzilai, Leonard Guarente, Thomas B L Kirkwood, Linda Partridge, Thomas A Rando, P Eline Slagboom

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players.International journal of environmental research and public health · 2022
    Article
  5. Genome Sequencing Variations in theFrontiers in aging neuroscience · 2022
    Article
  6. In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  7. Article
  8. Article
  9. Recent Advances in the Systems Biology of Aging.Antioxidants & redox signaling · 2018
    Review
  10. Article
  11. Review
  12. Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Article
  13. The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Article
  14. Article
  15. Article
  16. Article
  17. Quantification of biological aging in young adults.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nir BarzilaiAlbert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer Building, #701, Bronx, New York City, New York 10461, USA. nir.barzilai@einstein.yu.edu
Leonard Guarente
Thomas B L Kirkwood
Linda Partridge
Thomas A Rando
P Eline Slagboom

Funding

Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARGARET A. GOODELL · 2011 to 2026
$29.3M
NIA NIH HHS P01 AG036695
6 · The paper itself

Abstract

Rapidly increasing numbers of older people present many countries with growing social and economic challenges. Yet despite the far-reaching implications of ageing, its biological basis remains a topic of much debate. Recent advances in genomics have spurred research on ageing and lifespan in human populations, adding to extensive genetic studies being carried out in model organisms. But how far is ageing controlled by our genes? In this Viewpoint, six experts present their opinions and comment on future directions in ageing research.

Indexed as

AgingFemaleHumansLongevityMale

Identifiers

PMID22777128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.