Trial reportAnnals of biomedical engineering2012
Comparing pre- and post-operative Fontan hemodynamic simulations: implications for the reliability of surgical planning.
Trial report in Annals of biomedical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Surgical planning of the total cavopulmonary connection: robustness analysis.Annals of biomedical engineering · 2015Trial
- Article
- Applications of Computational Fluid Dynamics in Congenital Heart Disease: A Review.Journal of cardiovascular development and disease · 2025Review
- Multiphysiologic State Computational Fluid Dynamics Modeling for Planning Fontan With Interrupted Inferior Vena Cava.JACC. Advances · 2024Article
- In Silico Evaluation of a Self-powered Venous Ejector Pump for Fontan Patients.Cardiovascular engineering and technology · 2023Article
- Surgical Planning and Optimization of Patient-Specific Fontan Grafts With Uncertain Post-Operative Boundary Conditions and Anastomosis Displacement.IEEE transactions on bio-medical engineering · 2022Article
- Semi-Automatic Planning and Three-Dimensional Electrospinning of Patient-Specific Grafts for Fontan Surgery.IEEE transactions on bio-medical engineering · 2022Article
- Current state of the art in hypoplastic left heart syndrome.Frontiers in cardiovascular medicine · 2022Review
- Virtual treatment planning in three patients with univentricular physiology using computational fluid dynamics-Pitfalls and strategies.Frontiers in cardiovascular medicine · 2022Article
- Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease.Journal of cardiovascular development and disease · 2021Review
- Interventional Planning for Endovascular Revision of a Lateral Tunnel Fontan: A Patient-Specific Computational Analysis.Frontiers in physiology · 2021Article
- The first cohort of prospective Fontan surgical planning patients with follow-up data: How accurate is surgical planning?The Journal of thoracic and cardiovascular surgery · 2019Article
- Interventional Cardiology for Congenital Heart Disease.Korean circulation journal · 2018Review
- Fontan Surgical Planning: Previous Accomplishments, Current Challenges, and Future Directions.Journal of cardiovascular translational research · 2018Review
- Computational modelling for congenital heart disease: how far are we from clinical translation?Heart (British Cardiac Society) · 2017Review
- Can time-averaged flow boundary conditions be used to meet the clinical timeline for Fontan surgical planning?Journal of biomechanics · 2017Article
- Hemodynamic study of TCPC using in vivo and in vitro 4D Flow MRI and numerical simulation.Journal of biomechanics · 2015Article
- Relationship of single ventricle filling and preload to total cavopulmonary connection hemodynamics.The Annals of thoracic surgery · 2015Article
- Fontan hemodynamics from 100 patient-specific cardiac magnetic resonance studies: a computational fluid dynamics analysis.The Journal of thoracic and cardiovascular surgery · 2014Article
- Computational modeling of Fontan physiology: at the crossroads of pediatric cardiology and biomedical engineering.The international journal of cardiovascular imaging · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Virtual modeling of cardiothoracic surgery is a new paradigm that allows for systematic exploration of various operative strategies and uses engineering principles to predict the optimal patient-specific plan. This study investigates the predictive accuracy of such methods for the surgical palliation of single ventricle heart defects. Computational fluid dynamics (CFD)-based surgical planning was used to model the Fontan procedure for four patients prior to surgery. The objective for each was to identify the operative strategy that best distributed hepatic blood flow to the pulmonary arteries. Post-operative magnetic resonance data were acquired to compare (via CFD) the post-operative hemodynamics with predictions. Despite variations in physiologic boundary conditions (e.g., cardiac output, venous flows) and the exact geometry of the surgical baffle, sufficient agreement was observed with respect to hepatic flow distribution (90% confidence interval-14 ± 4.3% difference). There was also good agreement of flow-normalized energetic efficiency predictions (19 ± 4.8% error). The hemodynamic outcomes of prospective patient-specific surgical planning of the Fontan procedure are described for the first time with good quantitative comparisons between preoperatively predicted and postoperative simulations. These results demonstrate that surgical planning can be a useful tool for single ventricle cardiothoracic surgery with the ability to deliver significant clinical impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.