ReviewActa biomaterialia2012
The translational imperative: making cell therapy simple and effective.
Review in Acta biomaterialia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Equisetum hyemale enhances local bone regeneration in murine maxillary defects: an in vivo study.Odontology · 2026Article
- Therapeutic effects of dexamethasone-loaded hyaluronan nanogels in the experimental cholestasis.Drug delivery and translational research · 2022Article
- Perspective insights into hydrogels and nanomaterials for ischemic stroke.Frontiers in cellular neuroscience · 2022Review
- Hyaluronic Acid Facilitates Angiogenesis of Endothelial Colony Forming Cell Combining With Mesenchymal Stem CellFrontiers in bioengineering and biotechnology · 2022Article
- Hyaluronan-Based Grafting Strategies for Liver Stem Cell Therapy and Tracking Methods.Stem cells international · 2019Review
- Human neural stem cells dispersed in artificial ECM form cerebral organoids when grafted in vivo.Journal of anatomy · 2018Article
- Biochemical profiling of rat embryonic stem cells grown on electrospun polyester fibers using synchrotron infrared microspectroscopy.Analytical and bioanalytical chemistry · 2018Article
- Review
- Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells.Stem cell research & therapy · 2017Article
- Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance.American journal of respiratory cell and molecular biology · 2017Article
- Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine.International journal of molecular sciences · 2015Review
- Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels.Biomaterials · 2015Article
- Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells.Frontiers in cell and developmental biology · 2015Article
- Carboxymethyl Hyaluronan-Stabilized Nanoparticles for Anticancer Drug Delivery.International journal of cell biology · 2015Article
- Hyaluronan-Based Three-Dimensional Microenvironment Potently Induces Cardiovascular Progenitor Cell Populations.ISRN tissue engineering · 2013Article
- Article
- Review
- Intraocular Injection of HyStem Hydrogel Is Tolerated Well in the Rabbit Eye.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and TherapeuticsArticle
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The current practice of cell therapy, in which multipotent or terminally differentiated cells are injected into tissues or intravenously, is inefficient. Few therapeutic cells are retained at the site of administration and engraftment is low. An injectable and biologically appropriate vehicle for delivery, retention, growth and differentiation of therapeutic cells is needed to improve the efficacy of cell therapy. We focus on a hyaluronan-based semi-synthetic extracellular matrix (sECM), HyStem®, which is a manufacturable, approvable and affordable clinical product. The composition of this sECM can be customized for use with mesenchymal stem cells as well as cells derived from embryonic or induced pluripotent sources. In addition, it can support therapeutic uses of progenitor and mature cell populations obtained from skin, fat, liver, heart, muscle, bone, cartilage, nerves and other tissues. This overview presents four pre-clinical uses of HyStem® for cell therapy to repair injured vocal folds, improve post-myocardial infarct heart function, regenerate damaged liver tissue and restore brain function following ischemic stroke. Finally, we address the real-world limitations - manufacture, regulation, market acceptance and financing - surrounding cell therapy and the development of clinical combination products.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.