ReviewNeuropharmacology2013
Does interictal synchronization influence ictogenesis?
Review in Neuropharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Effect of Anti-Seizure Medications on Interictal Epileptiform Discharges in Focal Epilepsy.Clinical EEG and neuroscience · 2026Article
- Dynamic Interplay Between Wake Slow Waves and Epileptiform Discharges in the Epileptogenic Zone.Neurology · 2025Article
- The role of electroencephalography in epilepsy research-From seizures to interictal activity and comorbidities.Epilepsia · 2025Review
- The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep.PloS one · 2024Article
- An ictogenic marker in the mesial temporal epilepsy and its temporal evolutionary features.Frontiers in neurology · 2024Article
- High and Low-Frequency Stimulation Effect on Epileptiform Activity in Brain Slices.Medical journal of the Islamic Republic of Iran · 2023Article
- Article
- Active probing to highlight approaching transitions to ictal states in coupled neural mass models.PLoS computational biology · 2021Article
- Article
- Goldilocks Zone of Ictal Onset: Partially Recovered Synapses Provide the Kindling to Fuel Ictal Activity.Epilepsy currents · 2019Article
- Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations.Nature neuroscience · 2018Article
- Time and sex dependent effects of magnesium sulphate on post-asphyxial seizures in preterm fetal sheep.The Journal of physiology · 2018Article
- Initiation and slow propagation of epileptiform activity from ventral to dorsal medial entorhinal cortex is constrained by an inhibitory gradient.The Journal of physiology · 2018Article
- A predictive epilepsy index based on probabilistic classification of interictal spike waveforms.PloS one · 2018Article
- The Sub-Regional Functional Organization of Neocortical Irritative Epileptic Networks in Pediatric Epilepsy.Frontiers in neurology · 2018Article
- Spatiotemporal changes in regularity of gamma oscillations contribute to focal ictogenesis.Scientific reports · 2017Article
- Optogenetic Low-Frequency Stimulation of Specific Neuronal Populations Abates Ictogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy.Journal of neurophysiology · 2016Review
- Blockade of in vitro ictogenesis by low-frequency stimulation coincides with increased epileptiform response latency.Journal of neurophysiology · 2015Article
- Initiation, Propagation, and Termination of Partial (Focal) Seizures.Cold Spring Harbor perspectives in medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
The EEG recorded from epileptic patients presents with interictal discharges that are not associated with detectable clinical symptoms but are valuable for diagnostic purposes. Experimental studies have shown that interictal discharges and ictal events (i.e., seizures) are characterized intracellularly by similar (but for duration) neuronal depolarizations leading to sustained action potential firing, thus indicating that they may share similar cellular and pharmacological mechanisms. It has also been proposed that interictal discharges may herald the onset of electrographic seizures, but other studies have demonstrated that interictal events interfere with the occurrence of ictal activity. The relationship between interictal and ictal activity thus remains ambiguous. Here we will review this issue in animal models of limbic seizures that are electrographically close to those seen in TLE patients. In particular we will: (i) focus on the electrophysiological and pharmacological characteristics of, at least, two types of interictal discharge; (ii) propose that they play opposite roles in leading to ictogenesis; and (iii) discuss the possibility that mimicking one of these two types of interictal activity by low frequency repetitive stimulation can control ictogenesis. Finally, we will also review evidence indicating that specific types of interictal discharge may play a role in epileptogenesis. This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.