ReviewActa biologica Hungarica2012
Phylogenomics meets neuroscience: how many times might complex brains have evolved?
Review in Acta biologica Hungarica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Brief History of Ctenophora.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Analysis and Visualization of Single-Cell Sequencing Data with Scanpy and MetaCell: A Tutorial.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Homologous vs. homocratic neurons: revisiting complex evolutionary trajectories.Frontiers in cell and developmental biology · 2023Article
- Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
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- Independent origins of neurons and synapses: insights from ctenophores.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- The neuromuscular system ofEvoDevo · 2016Article
- Where is my mind? How sponges and placozoans may have lost neural cell types.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Biodiversity Meets Neuroscience: From the Sequencing Ship (Ship-Seq) to Deciphering Parallel Evolution of Neural Systems in Omic's Era.Integrative and comparative biology · 2015Review
- Convergent evolution of neural systems in ctenophores.The Journal of experimental biology · 2015Review
- A common evolutionary origin for the ON- and OFF-edge motion detection pathways of the Drosophila visual system.Frontiers in neural circuits · 2015Article
- The genealogy of genealogy of neurons.Communicative & integrative biology · 2014Review
- Article
Corrections and comments
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Abstract
The origin of complex centralized brains is one of the major evolutionary transitions in the history of animals. Monophyly (i.e. presence of a centralized nervous system in urbilateria) vs polyphyly (i.e. multiple origins by parallel centralization of nervous systems within several lineages) are two historically conflicting scenarios to explain such transitions. However, recent phylogenomic and cladistic analysis suggests that complex brains may have independently evolved at least 9 times within different animal lineages. Indeed, even within the phylum Mollusca cephalization might have occurred at least 5 times. Emerging molecular data further suggest that at the genomic level such transitions might have been achieved by changes in expression of just a few transcriptional factors - not surprising since such events might happen multiple times over 700 million years of animal evolution. Both cladistic and genomic analyses also imply that neurons themselves evolved more than once. Ancestral polarized secretory cells were likely involved in coordination of ciliated locomotion in early animals, and these cells can be considered as evolutionary precursors of neurons within different lineages. Under this scenario, the origins of neurons can be linked to adaptations to stress/injury factors in the form of integrated regeneration-type cellular response with secretory signaling peptides as early neurotransmitters. To further reconstruct the parallel evolution of nervous systems genomic approaches are essential to probe enigmatic neurons of basal metazoans, selected lophotrochozoans (e.g. phoronids, brachiopods) and deuterostomes.
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